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首页> 美国卫生研究院文献>Translational Lung Cancer Research >This special volume of mesothelioma is dedicated to my friend Adi Gazdar
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This special volume of mesothelioma is dedicated to my friend Adi Gazdar

机译：间皮瘤的这本特别的书专门献给我的朋友阿迪·加兹达尔（Adi Gazdar）

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As of today, Adi has >130,000 citations and an H-index of 175. Adi was the “father” of what it is now known as molecular pathology. Trained as a classic pathologist at Harvard, he applied molecular biology to pathology and elucidated the genetic alterations of lung cancer. In other words, he revolutionized the world of pathology using molecular biology. He established many cell lines, one of them was the ONLY cell line in which retroviruses grew: it was used to discover first HTLV1, and later to isolate and grow HIV. Adi told me: without my cell line, NCI would have closed all retro-virology labs! I met him at a meeting where I presented my work showing that SV40 DNA was present in some human mesotheliomas. He told me: I do not believe your data, I will test your hypothesis in my lab and disprove your findings. Yes, he spoke his mind, very directly, I was scared, he was quite famous, I was just a "kid". He called me a few months later, he said remember me? Sure, Dr. Gazdar, so? So you were right! I laser microdissected mesothelioma and nearby normal tissue and found SV40 only in tumor cells. Since then we became friends!
机译：截止到今天，Adi被引用的次数超过130,000，H指数为175。Adi是如今被称为分子病理学的“父亲”。在哈佛大学接受经典病理学家培训后，他将分子生物学应用于病理学，并阐明了肺癌的基因改变。换句话说，他使用分子生物学彻底改变了病理学领域。他建立了许多细胞系，其中之一是逆转录病毒在其中生长的唯一细胞系：首先用于发现HTLV1，然后用于分离和生长HIV。阿迪告诉我：如果没有我的细胞系，NCI将会关闭所有逆转录病毒实验室！我在一次会议上认识了他，在会议上我展示了我的工作，结果表明SV40 DNA存在于某些人类间皮瘤中。他告诉我：我不相信您的数据，我会在实验室中检验您的假设并反驳您的发现。是的，他很直接地说出了主意，我很害怕，他很出名，我只是个“孩子”。几个月后他打电话给我，他说还记得我吗？当然，Gazdar博士，是吗？所以你是对的！我激光显微切割了间皮瘤和附近正常组织，仅在肿瘤细胞中发现了SV40。从此我们成为了朋友！

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