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首页> 美国卫生研究院文献>Vaccines >Emergency Foot-and-Mouth Disease Vaccines A Malaysia 97 and A22 Iraq 64 Offer Good Protection against Heterologous Challenge with A Variant Serotype A ASIA/G-IX/SEA-97 Lineage Virus
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Emergency Foot-and-Mouth Disease Vaccines A Malaysia 97 and A22 Iraq 64 Offer Good Protection against Heterologous Challenge with A Variant Serotype A ASIA/G-IX/SEA-97 Lineage Virus

机译：紧急口蹄疫疫苗A马来西亚97和A22伊拉克64用变异的A型血清型ASIA / G-IX / SEA-97谱系病毒提供了良好的保护可抵抗异源攻击

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The continuous emergence of foot-and-mouth disease virus (FMDV) serotype A variants in South East Asia is of concern for international FMDV antigen banks, especially when in vitro tests predict a low antigenic match. A vaccination-challenge study was performed by using two emergency FMDV vaccines with A Iraq 64 (A22 IRQ) and A Malaysia 97 (A MAY 97) strains, against challenge with a variant strain of FMDV A/Asia/G-IX/SEA-97 lineage at 7- and 21-day post-vaccination (dpv). At 7 dpv, three of five female calves vaccinated with A MAY 97 and four of five vaccinated with A22 IRQ did not show lesions on the feet and were considered protected, while at 21 dpv all five calves were protected with each vaccine, indicating equal efficacy of both vaccine strains. Calves were protected despite relatively low heterologous neutralizing antibody titers to the challenge virus at the time of challenge. All the calves developed antibodies to the non-structural proteins, most likely due to the direct intradermolingual (IDL) inoculation. Only one calf from the A MAY 97-7 group had infectious virus in the serum 1–3-day post-challenge (dpc), while no virus could be isolated from the serum of cattle challenged on 21 dpv. The virus could be isolated from the oral swabs of all calves, 1–7 dpc with viral RNA detected 1–10 dpc. Nasal swabs were positive for virus 1–6 dpc in a small number of calves. The time between vaccination and infection did not have an impact on the number of animals with persistent infection, with almost all the animals showing viral RNA in their oro-pharyngeal fluid (probang) samples up to 35 dpc. Despite the poor in vitro matching data and field reports of vaccine failures, this study suggests that these vaccine strains should be effective against this new A/Asia/G/SEA-97 variant, provided they are formulated with a high antigen dose.
机译：口蹄疫病毒（FMDV）血清型A变种在东南亚地区的不断出现引起国际FMDV抗原库的关注，尤其是在体外试验预测抗原匹配低的情况下。通过使用两种紧急FMDV疫苗（分别为A伊拉克64（A22 IRQ）和马来西亚97（A MAY 97））对FMDV A / Asia / G-IX / SEA-接种后7天和21天有97个血统。在7 dpv时，接种A MAY 97的五只雌性小牛中有三只，而用A22 IRQ接种的五只小牛中有四只未显示脚部病变，被认为是受到保护的，而在21 dpv时，每种疫苗都对五只小牛进行了保护，表明功效相同两种疫苗株。尽管在攻击时对攻击病毒的异源中和抗体滴度相对较低，但小牛仍受到保护。所有的小牛都产生了针对非结构蛋白的抗体，这很可能是由于直接的分子内分子内（IDL）接种。挑战后1-3天（dpc），只有来自A MAY 97-7组的一头小牛的血清中具有传染性病毒，而在21 dpv攻击的牛血清中没有分离出病毒。可以从所有小牛的口腔拭子1–7 dpc中分离出病毒，并检测到病毒RNA 1–10 dpc。少数牛犊中的鼻拭子对1-6 dpc病毒呈阳性反应。接种疫苗和感染之间的时间对持续感染的动物数量没有影响，几乎所有动物的咽咽液（probang）样品中显示的病毒RNA高达35 dpc。尽管体外匹配数据和疫苗失败的现场报道不多，但这项研究表明，只要这些疫苗菌株配制高抗原剂量，它们就可以有效对抗这种新的A / Asia / G / SEA-97变异株。

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