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首页> 美国卫生研究院文献>The FASEB Journal >Induction of activity synchronization among primed hippocampal neurons out of random dynamics is key for trace memory formation and retrieval
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Induction of activity synchronization among primed hippocampal neurons out of random dynamics is key for trace memory formation and retrieval

机译：在随机动力学中引发引发的海马神经元之间的活动同步是痕量记忆形成和检索的关键

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Memory is thought to be encoded by sparsely distributed neuronal ensembles in memory‐related regions. However, it is unclear how memory‐eligible neurons react during learning to encode trace fear memory and how they retrieve a memory. We implemented a fiber‐optic confocal fluorescence endomicroscope to directly visualize calcium dynamics of hippocampal CA1 neurons in freely behaving mice subjected to trace fear conditioning. Here we report that the overall activity levels of CA1 neurons showed a right‐skewed lognormal distribution, with a small portion of highly active neurons (termed Primed Neurons) filling the long‐tail. Repetitive training induced Primed Neurons to shift from random activity to well‐tuned synchronization. The emergence of activity synchronization coincided with the appearance of mouse freezing behaviors. In recall, a partial synchronization among the same subset of Primed Neurons was induced from random dynamics, which also coincided with mouse freezing behaviors. Additionally, training‐induced synchronization facilitated robust calcium entry into Primed Neurons. In contrast, most CA1 neurons did not respond to tone and foot shock throughout the training and recall cycles. In conclusion, Primed Neurons are preferably recruited to encode trace fear memory and induction of activity synchronization among Primed Neurons out of random dynamics is critical for trace memory formation and retrieval.
机译：记忆被认为是由记忆相关区域中稀疏分布的神经元集合编码的。但是，尚不清楚适合记忆的神经元在学习编码痕迹恐惧记忆时如何反应以及如何恢复记忆。我们实施了光纤共聚焦荧光内窥镜，以直接可视化遭受痕量恐惧条件的行为自由的小鼠中海马CA1神经元的钙动力学。在这里，我们报告说，CA1神经元的总体活动水平显示出右偏对数正态分布，而一小部分高度活跃的神经元（称为初等神经元）填补了长尾。重复训练导致“激发神经元”从随机活动转变为协调良好的同步。活动同步的出现与鼠标冻结行为的出现相吻合。回想起来，随机动力学诱发了相同的引发神经元子集之间的部分同步，这也与鼠标的冻结行为相吻合。此外，训练诱发的同步促进钙大量进入致敏神经元。相比之下，大多数CA1神经元在整个训练和回忆周期中对音调和足部休克均无反应。总之，最好招募初等神经元来编码痕量恐惧记忆，并且在随机动力学之外引发初等神经元之间的活动同步对于痕量记忆的形成和恢复至关重要。

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