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Measurement of myocardial blood flow by cardiovascular magnetic resonance perfusion: comparison of distributed parameter and Fermi models with single and dual bolus

机译:通过心血管磁共振灌注测量心肌血流量:单次推注和双重推注的分布参数和费米模型的比较

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摘要

BackgroundMathematical modeling of cardiovascular magnetic resonance perfusion data allows absolute quantification of myocardial blood flow. Saturation of left ventricle signal during standard contrast administration can compromise the input function used when applying these models. This saturation effect is evident during application of standard Fermi models in single bolus perfusion data. Dual bolus injection protocols have been suggested to eliminate saturation but are much less practical in the clinical setting. The distributed parameter model can also be used for absolute quantification but has not been applied in patients with coronary artery disease. We assessed whether distributed parameter modeling might be less dependent on arterial input function saturation than Fermi modeling in healthy volunteers. We validated the accuracy of each model in detecting reduced myocardial blood flow in stenotic vessels versus gold-standard invasive methods.
机译:背景技术心血管磁共振灌注数据的数学建模允许对心肌血流进行绝对定量。在应用标准对比剂时,左心室信号的饱和度可能会损害使用的输入功能。在单次大剂量灌注数据中应用标准费米模型期间,这种饱和效应很明显。已建议使用双推注注射方案来消除饱和,但在临床环境中实用性要差得多。分布参数模型也可以用于绝对定量,但尚未用于冠心病患者。我们评估了在健康志愿者中,分布式参数建模是否比Fermi建模更不依赖于动脉输入功能饱和度。我们验证了每个模型在检测狭窄血管中心肌血流量相对于金标准侵入性方法方面的准确性。

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