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首页> 美国卫生研究院文献>Maternal Child Nutrition >Comparison of the effectiveness of a milk‐free soy‐maize‐sorghum‐based ready‐to‐use therapeutic food to standard ready‐to‐use therapeutic food with 25 milk in nutrition management of severely acutely malnourished Zambian children: an equivalence non‐blinded cluster randomised controlled trial
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Comparison of the effectiveness of a milk‐free soy‐maize‐sorghum‐based ready‐to‐use therapeutic food to standard ready‐to‐use therapeutic food with 25 milk in nutrition management of severely acutely malnourished Zambian children: an equivalence non‐blinded cluster randomised controlled trial

机译：在严重急性营养不良的赞比亚儿童的营养管理中将不含牛奶的玉米-玉米-高粱类即食治疗食品与含25％牛奶的标准即食治疗食品的有效性进行比较：等效盲组随机对照试验

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ommunity‐based anagement of cute alnutrition using eady‐to‐ se herapeutic ood ( ) has revolutionised the treatment of severe acute malnutrition ( ). However, 25% milk content in standard peanut‐based ( ‐RUTF) makes it too expensive. The effectiveness of milk‐free has not been reported hitherto. This non‐blinded, parallel group, cluster randomised, controlled, equivalence trial that compares the effectiveness of a milk‐free soy–maize–sorghum‐based ( ‐ ) with ‐RUTF in treatment of children with , closes the gap. A statistician randomly assigned health centres ( ) either to the ‐ (  = 12; 824 enrolled) or ‐ (  = 12; 1103 enrolled) arms. All children admitted at the participating s were enrolled. All the outcomes were measured at individual level. Recovery rate was the primary outcome. The recovery rates for ‐ and ‐ were 53.3% and 60.8% for the intention‐to‐treat ( ) analysis and 77.9% and 81.8% for per protocol ( ) analyses, respectively. The corresponding adjusted risk difference ( ) and 95% confidence interval, were −7.6% (−14.9, 0.6%) and −3.5% (−9,6., 2.7%) for (  = 0.034) and analyses (  = 0.257), respectively. An unanticipated interaction (interaction  ITT analyses and 0.0683 for analyses) between the study arm and age group was observed. The s were −10.0 (−17.7 to −2.3)% for (  = 0.013) and −4.7 (−10.0 to 0.7) for (  = 0.083) analyses for the <24 months age group and 2.1 (−10.3,14.6)% for (  = 0.726) and −0.6 (−16.1, 14.5) for (  = 0.939) for the ≥24 months age group. In conclusion, the study did not confirm our hypothesis of equivalence between ‐ and ‐ in management.
机译：使用易治性软膏（）进行基于团体免疫的可爱营养餐（）彻底改变了严重急性营养不良（）的治疗方法。但是，标准花生酱（‐RUTF）中25％的牛奶含量使其太昂贵了。迄今为止，无牛奶的有效性尚未见报道。这项非盲，平行，分组，随机，对照，等价试验比较了无乳大豆-玉米-高粱基（‐）和‐RUTF在治疗Ⅱ期儿童中的有效性，从而缩小了差距。统计学家将健康中心（）随机分配给‐（= 12;已入组824）或‐-（= 12;已入组1103）。所有参加该计划的学生都已入学。所有结果均在个体水平上进行测量。恢复率是主要结果。意向治疗（）分析的回收率分别为53.3％和60.8％，每种方案（）分析的回收率分别为77.9％和81.8％。 （= 0.034）和分析（= 0.257）的相应调整后风险差异（）和95％置信区间为-7.6％（−14.9，0.6％）和-3.5％（−9,6。，2.7％），分别。研究组和年龄组之间发生了意料之外的相互作用（相互作用ITT分析和0.0683分析）。 <24个月年龄组的s为（= 0.013）的-10.0（−17.7至-2.3）％和（（= 0.083）分析的s为-4.7（−10.0至0.7），而s为2.1（−10.3,14.6）％ ≥24个月年龄组（= 0.939）的（= 0.726）和-0.6（−16.1，14.5）。总而言之，该研究并未证实我们关于“管理”与“管理”相等的假设。

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