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首页> 美国卫生研究院文献>The Journal of Clinical Investigation >Effects of thyroid-stimulating hormone on adenyl cyclase activity and intermediary metabolism of cold thyroid nodules and normal human thyroid tissue
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Effects of thyroid-stimulating hormone on adenyl cyclase activity and intermediary metabolism of cold thyroid nodules and normal human thyroid tissue

机译：促甲状腺激素对冷甲状腺结节和正常人甲状腺组织腺苷酸环化酶活性和中间代谢的影响

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摘要

“Cold” thyroid nodules do not concentrate 131I before or after thyrotropin (TSH) administration. In an attempt to elucidate the reason for this TSH unresponsiveness, the effect of TSH in vitro on several metabolic parameters was studied in 11 “cold” thyroid adenomas, 2 medullary carcinomas, and in the surrounding normal thyroid tissue. Basal adenyl cyclase activity, glucose-1-14C oxidation, and 32P incorporation into phospholipids were significantly greater in the adenomas than in the adjacent normal thyroid; basal cyclic 3′,5′-adenosine monophosphate (cyclic AMP) concentration and adenine-3H incorporation into 3H-labeled cyclic AMP were not different. In adenomas as well as normal thyroid, all parameters responded significantly to in vitro TSH stimulation. The response to TSH of adenyl cyclase activity and 32P incorporation was enhanced in adenomas compared with that of the adjacent normal thyroid. These differences were not explained by an increased cellularity of the adenomas. Medullary carcinomas did not respond to TSH in any of the above parameters.The studies demonstrate an intact, TSH-responsive adenyl cyclase-cyclic AMP system in the adenomas and, accordingly, imply the presence of receptor sites for TSH on the cells of the adenoma. The failure of such nodules to concentrate 131I may be owing to a subsequent impairment in the expression of cyclic AMP action on iodine metabolism.
机译：在施用促甲状腺激素（TSH）之前或之后，“冷”甲状腺结节不会浓缩 131 I。为了阐明TSH反应迟钝的原因，在11种“冷”甲状腺腺瘤，2种髓样癌以及周围正常甲状腺组织中研究了TSH体外对几种代谢参数的影响。腺瘤中基础腺苷酸环化酶活性，葡萄糖-1- 14 C氧化和 32 P掺入磷脂的比例明显高于邻近的正常甲状腺。基础环状3'，5'-单磷酸腺苷（环状AMP）的浓度和腺嘌呤- 3 H掺入 3 H标记的环状AMP中没有差异。在腺瘤和正常甲状腺中，所有参数均对体外TSH刺激有明显反应。与邻近的正常甲状腺相比，腺瘤中腺苷酸环化酶活性和 32 P掺入对TSH的反应增强。这些差异不能通过腺瘤细胞增多来解释。髓样癌对上述任何参数均不产生TSH反应。研究表明，腺瘤中完整的TSH反应性腺苷酸环化酶-环AMP系统存在，因此暗示腺瘤细胞中存在TSH受体位点。 。这种结节未能浓缩 131 I的原因可能是由于环AMP对碘代谢的作用随后受损所致。

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