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Ecology of zoonoses: natural and unnatural histories

机译:人畜共患病的生态学:自然和非自然历史

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摘要

More than 60% of human infectious diseases are caused by pathogens shared with wild or domestic animals. Zoonotic disease organisms include those that are endemic in human populations or enzootic in animal populations with frequent cross-species transmission to people. Some of these diseases have only emerged recently. Together, these organisms are responsible for a substantial burden of disease, with endemic and enzootic zoonoses causing about a billion cases of illness in people and millions of deaths every year. Emerging zoonoses are a growing threat to global health and have caused hundreds of billions of US dollars of economic damage in the past 20 years. We aimed to review how zoonotic diseases result from natural pathogen ecology, and how other circumstances, such as animal production, extraction of natural resources, and antimicrobial application change the dynamics of disease exposure to human beings. In view of present anthropogenic trends, a more effective approach to zoonotic disease prevention and control will require a broad view of medicine that emphasises evidence-based decision making and integrates ecological and evolutionary principles of animal, human, and environmental factors. This broad view is essential for the successful development of policies and practices that reduce probability of future zoonotic emergence, targeted surveillance and strategic prevention, and engagement of partners outside the medical community to help improve health outcomes and reduce disease threats.
机译:超过60%的人类传染病是由与野生或家畜共有的病原体引起的。人畜共患疾病的生物包括人类人群中特有的动物物种或动物种群中的动物共生动物,它们经常通过跨物种传播给人类。其中一些疾病只是最近才出现。这些生物共同造成了巨大的疾病负担,地方性和人畜共患的人畜共患疾病每年造成约10亿人的疾病病例和数百万人的死亡。新兴的人畜共患病对全球健康的威胁越来越大,在过去20年中造成了数千亿美元的经济损失。我们旨在审查人畜共患疾病如何由自然病原体生态导致,以及其他情况(例如动物生产,自然资源的提取和抗菌剂的应用)如何改变人类疾病暴露的动态。鉴于当前的人为趋势,一种更有效的人畜共患病预防和控制方法将需要广泛的医学视野,强调基于证据的决策并整合动物,人类和环境因素的生态和进化原理。这种广泛的观点对于成功制定减少未来人畜共患病可能性,有针对性的监测和战略预防以及减少医学界外部合作伙伴参与以帮助改善健康结果和减少疾病威胁的政策和实践至关重要。

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