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Fine level epitope mapping and conservation analysis of two novel linear B-cell epitopes of the avian infectious bronchitis coronavirus nucleocapsid protein

机译：禽传染性支气管炎冠状病毒核衣壳蛋白的两个新型线性B细胞表位的精细水平表位作图和保守性分析

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摘要

► Infectious bronchitis virus is one of the most important coronavirus causing respiratory disease in chicken. ► Analysis of protein epitope in virus could provide important insights that could facilitate the development of specific diagnostics and further understanding of the antigenic structure of protein. ► Two linear B-cell epitopes that were recognized by the mAbs 6D10 and 4F10, which corresponded to the amino acid sequences FGPRTK and DLIARAAKI , respectively, in the IBV N protein. ► The two epitopes are very conserved among IBV serotypes.

机译：►传染性支气管炎病毒是引起鸡呼吸系统疾病的最重要的冠状病毒之一。 ►分析病毒中的蛋白质表位可以提供重要的见解，可以促进特定诊断方法的开发和对蛋白质抗原结构的进一步了解。 ►单克隆抗体6D10和4F10识别的两个线性B细胞表位，分别对应于IBV N蛋白中的氨基酸序列FGPRTK和DLIARAAKI。 ►在IBV血清型中，这两个表位非常保守。

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期刊名称 Elsevier Public Health Emergency Collection
作者
Zongxi Han; Fei Zhao; Yuhao Shao; Xiaoli Liu; Xiangang Kong; Yang Song; Shengwang Liu;
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作者单位

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年(卷),期 -1(171),1
年度 -1
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Avian infectious; Bronchitis; Coronavirus; Epitope; Monoclonal antibody; Nucleocapsid protein; Phylogenetic analysis;

机译：禽传染;支气管炎;冠状病毒;表位;单克隆抗体;核衣壳蛋白;系统发育分析;

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专利

1. Fine level epitope mapping and conservation analysis of two novel linear B-cell epitopes of the avian infectious bronchitis coronavirus nucleocapsid protein [J] . HanZ., ZhaoF., ShaoY., Virus Research: An International Journal of Molecular and Cellular Virology . 2013,第1期

机译：禽传染性支气管炎冠状病毒核衣壳蛋白的两个新型线性B细胞表位的精细水平表位作图和保守性分析
2. Identification of a Novel Linear B-Cell Epitope in the M Protein of Avian Infectious Bronchitis Coronaviruses [J] . Junji Xing, Shengwang Liu, Zongxi Han, The journal of microbiology . 2009,第5期

机译：禽传染性支气管炎冠状病毒M蛋白中新型线性B细胞表位的鉴定
3. Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus hemagglutinin protein [J] . Veterinary Microbiology . 2017,第期

机译：PESTE DES PETINS VININ病毒血凝素蛋白线性B细胞表位的细制与保护分析
4. B-cell epitope mapping of Helicobacter pylori neutrophil-activating protein [C] . Chibing Gong, Yan Li, Ming Li, Frontiers in the Convergence of Bioscience and Information Technologies . 2007

机译：幽门螺杆菌中性粒细胞活性蛋白的B细胞表位映射
5. Avian Infectious Bronchitis Coronavirus Variation and Selection. [D] . Gallardo, Rodrigo A. 2011

机译：禽传染性支气管炎冠状病毒变异和选择。
6. Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus hemagglutinin protein [O] . Ruisong Yu, Rui Zhu, Weixiang Gao, -1

机译：小反刍动物病毒血凝素蛋白线性B细胞表位的精细定位和保守性分析
7. Fine level epitope mapping and conservation analysis of two novel linear B-cell epitopes of the avian infectious bronchitis coronavirus nucleocapsid protein [O] . Zongxi Han, Fei Zhao, Yuhao Shao, 2013

机译：禽传染性支气管炎冠状病毒核蛋白蛋白蛋白两种新型线性B细胞表位的细水位表位测绘与保护分析
8. Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope based DNA vaccine able to focus the antibody response in mice. [R] . Schmaljohn, C. 2017

机译：埃博拉病毒显性和次优势糖蛋白表位的表位作图有助于构建能够将抗体反应集中在小鼠中的基于表位的DNa疫苗。

Fine level epitope mapping and conservation analysis of two novel linear B-cell epitopes of the avian infectious bronchitis coronavirus nucleocapsid protein

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