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首页> 美国卫生研究院文献>The Journal of Clinical Investigation >Glomerular Endothelial Cells in Uranyl Nitrate-induced Acute Renal Failure in Rats
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Glomerular Endothelial Cells in Uranyl Nitrate-induced Acute Renal Failure in Rats

机译：硝酸铀酰诱导的大鼠急性肾功能衰竭肾小球内皮细胞

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In uranyl nitrate (UN)-induced acute renal failure (ARF) glomerular ultrafiltration coefficient (Kf) decreases because of unknown reasons. Since transport of water across the glomerular capillary wall occurs predominantly extracellularly through the endothelial fenestrae (EF), a reduction in the diameter and/or the density of EF can reduce the extracellular filtration area and the glomerular Kf. To examine this possibility, ARF was induced in rats by intravenous administration of UN in low (15 mg/kg) and high doses (25 mg/kg). Fenestral density (¯x±SEM) per 5 cm2 from the scanning electron micrographs (×30,000) was 107±10, 103±9, and 101±11 at 2, 7, and 17 h after the intravenous administration of bicarbonate saline to the control rats. In the low-dose UN group the EF density was 91±2, 52±8, and 45±11 at 2, 7, and 17 h after the injection, whereas for the high-dose group at corresponding time intervals the EF density was 95±3, 54±9, and 44±10. Fenestral diameters, in Angstrom units (¯x±SEM), were 751±53, 765±43, and 764±37 at 2, 7, and 17 h after the injection of bicarbonate saline to control rats. At corresponding intervals after the administration of UN, the fenestral diameters were 501±61, 472±28, and 438±98 for the low-dose group and 525±43, 470±39, and 440±56 for the high-dose group. 2, 7, and 17 h after the injection of UN, fenestral area of the low-dose group decreased to 52.1, 30.1, and 24.6% of the controls, whereas in the high-dose group, the fenestral area declined to 54.3, 30.2, and 23.6% of the controls. Administration of UN (15 mg/kg) to sodium-loaded rats did not alter renal function or endothelial cell morphology. It is suggested that in UN-induced ARF the morphological alterations in endothelial cells reduce the Kf of glomerular capillaries by reducing the filtration area.
机译：由于未知原因，在硝酸铀酰（UN）诱导的急性肾衰竭（ARF）中，肾小球超滤系数（Kf）降低。由于水通过肾小球毛细血管壁的运输主要发生在内皮外窗孔（EF）的细胞外，因此EF直径和/或密度的减小可减少细胞外过滤面积和肾小球Kf。为了检验这种可能性，通过低剂量（15 mg / kg）和高剂量（25 mg / kg）的UN静脉内给药在大鼠中诱发了ARF。扫描电子显微镜（×30,000）的每5 cm 2 的女性密度（¯x±SEM）在2、7和17小时后分别为107±10、103±9和101±11向对照组大鼠静脉注射碳酸氢盐盐水。在低剂量联合国组中，注射后2、7和17小时的EF密度为91±2、52±8和45±11，而对于大剂量组，在相应的时间间隔，EF密度为95±3、54±9和44±10。在向对照大鼠注射碳酸氢盐盐水后的2、7和17小时，nes直径（埃x±SEM）为751±53、765±43和764±37。服用UN后的相应间隔，小剂量组的nes骨直径为501±61、472±28和438±98，高剂量组的为525±43、470±39和440±56 。注射UN后第2、7和17小时，低剂量组的股骨面积减少至对照组​​的52.1、30.1和24.6％，而在大剂量组中，股骨面积减少至54.3、30.2 ，以及对照组的23.6％。向钠负荷的大鼠施用UN（15 mg / kg）不会改变肾功能或内皮细胞形态。提示在联合国诱发的ARF中，内皮细胞的形态改变可通过减少滤过面积来降低肾小球毛细血管的Kf。

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