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首页> 美国卫生研究院文献>The Journal of Clinical Investigation >Relationship between regional myocardial blood flow and thallium-201 distribution in the presence of coronary artery stenosis and dipyridamole-induced vasodilation.
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Relationship between regional myocardial blood flow and thallium-201 distribution in the presence of coronary artery stenosis and dipyridamole-induced vasodilation.

机译：冠状动脉狭窄和双嘧达莫引起的血管舒张时局部心肌血流量与th201分布的关系。

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This study assesses the relationship between the distribution of thallium-201 and myocardial blood flow during coronary vasodilation induced by intravenous dipyridamole in canine models of partial and complete coronary artery stenosis. 10 dogs were chronically instrumented with catheters in the left atrium and aorta and with a balloon occluder and electromagnetic flow probe on the proximal left circumflex coronary artery. Regional myocardial blood flow was measured during control conditions with radioisotope-labeled microspheres, and the phasic reactive hyperemic response to a 20-s transient occlusion was then recorded. Dipyridamole was then infused intravenously until phasic coronary blood flow increased to match peak hyperemic values. The left circumflex coronary artery was either partially occluded to reduce phasic blood flow to control values (group 1) or it was completely occluded (group 2), and thallium-201 and a second microsphere label were injected. 5 min later, the animals were sacrificed, the left ventricle was sectioned into 1-2-g samples, and thallium-201 activity and regional myocardial blood flow were measured. Curvilinear regression analyses between thallium-201 localization and myocardial blood flow during dipyridamole infusion demonstrated a slightly better fit to a second- as compared with a first-order model, indicating a slight roll-off of thallium activity as myocardial blood flow increases. During the dipyridamole infusion, the increases in phasic blood flow, the distributions of regional myocardial blood flow, and the relationships between thallium-201 localization and regional blood flow were comparable to values previously observed in exercising dogs with similar occlusions. These data provide basic validation that supports the use of intravenous dipyridamole and thallium-201 as an alternative to exercise stress and thallium-201 for evaluating the effects of coronary occlusive lesions on the distribution of regional myocardial blood flow.
机译：本研究评估了在部分和完全冠状动脉狭窄的犬模型中静脉注射双嘧达莫引起的冠状动脉舒张过程中201201的分布与心肌血流之间的关系。长期对10只犬进行了左心房和主动脉导管置入术，并在左旋支扬长动脉近端用气囊封堵器和电磁流量探针进行了长期检测。用放射性同位素标记的微球在对照条件下测量区域性心肌血流，然后记录对20 s短暂闭塞的阶段性反应性充血反应。然后，对双嘧达莫进行静脉输注，直到冠状动脉血流逐渐增加以匹配充血峰值。左旋支冠状动脉或者部分阻塞以减少相间血流至控制值（第1组），或者完全阻塞（第2组），并注射th 201和第二个微球标记。 5分钟后，处死动物，将左心室切成1-2-g样品，并测量th201的活性和局部心肌血流量。潘生丁输注期间th201定位与心肌血流之间的曲线回归分析显示，与一阶模型相比，to二酮的拟合度稍好，表明as活性随心肌血流增加而略有下降。在双嘧达莫输注期间，相移血流的增加，区域心肌血流的分布以及th201定位与区域血流之间的关系与先前在具有类似咬合的运动犬中观察到的值相当。这些数据提供了基础验证，支持使用静脉注射双嘧达莫和al 201替代运动压力，并使用-201评价冠状动脉闭塞性病变对局部心肌血流分布的影响。

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