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首页> 美国卫生研究院文献>The Journal of Clinical Investigation >Pituitary self-priming actions of gonadotropin-releasing hormone. Kinetics of estradiols potentiating effects on gonadotropin-releasing hormone-facilitated luteinizing hormone and follicle-stimulating hormone release in healthy postmenopausal women.
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Pituitary self-priming actions of gonadotropin-releasing hormone. Kinetics of estradiols potentiating effects on gonadotropin-releasing hormone-facilitated luteinizing hormone and follicle-stimulating hormone release in healthy postmenopausal women.

机译：促性腺激素释放激素的垂体自启动作用。雌二醇对健康绝经后妇女促性腺激素释放激素促黄体生成激素和促卵泡激素释放的增强作用动力学。

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摘要

We examined the kinetically distinct characteristics of estradiol's effects upon pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release in response to pulses of exogenous gonadotropin-releasing hormone (GnRH) in healthy postmenopausal individuals. The putative self-priming actions of GnRH on LH and FSH release were tested by intravenous injections of equal paired doses of GnRH (10 micrograms) before and after 1, 5, 10, and 30 d of pure estradiol-17 beta delivery via an intravaginal silastic ring. Self-priming actions of GnRH, as defined by heightened gonadotropin release in response to the second pulse of GnRH compared with the first, were completely absent in the hypoestrogenemic state. However, estradiol administration unmasked GnRH self-priming in a time-dependent fashion, with maximal expression after 5 and 10 d of steroid replacement, followed by attenuation by 30 d. Since estradiol's modulation of GnRH action was expressed differentially on LH and FSH release, we suggest that such facilitation of GnRH-stimulated pituitary LH and FSH release may provide an additional mechanism for dissociated secretion of gonadotropic hormones in health or disease.
机译：我们检查了绝经后健康个体中雌二醇对垂体促黄体生成激素（LH）和促卵泡激素（FSH）释放的响应的动力学独特特征，以响应外源促性腺激素释放激素（GnRH）的脉冲。通过在阴道内通过纯净的雌二醇-17 beta输送1、5、10和30 d之前和之后静脉内注射相等剂量的GnRH（10微克）配对，测试了GnRH对LH和FSH释放的推定自引发作用硅橡胶环。在低雌激素生成状态下，完全不存在GnRH的自引发作用，这是由响应于GnRH的第二个脉冲的促性腺激素释放增加所定义的。然而，雌二醇的给药以时间依赖性方式掩盖了GnRH的自引发作用，在类固醇置换5和10 d后表达最大，随后衰减30 d。由于雌二醇对GnRH作用的调节在LH和FSH释放上有差异地表达，因此我们认为这种促进GnRH刺激的垂体LH和FSH释放可能为健康或疾病中促性腺激素的分泌解离提供了额外的机制。

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