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首页> 美国卫生研究院文献>The Journal of Clinical Investigation >Effect of the long-term administration of corticotropin-releasing factor on the pituitary-adrenal and pituitary-gonadal axis in the male rat.
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Effect of the long-term administration of corticotropin-releasing factor on the pituitary-adrenal and pituitary-gonadal axis in the male rat.

机译：长期服用促肾上腺皮质激素释放因子对雄性大鼠垂体-肾上腺和垂体-性腺轴的影响。

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The effect of the continuous exposure to ovine corticotropin-releasing factor (oCRF) was measured in adult male rats. The intravenous infusion of 0.75 nmol oCRF/h to intact rats over a 24-h period was accompanied by a peak of ACTH and corticosterone secretion that occurred during the first 90 min of administration of the releasing factor, followed by a decrease to lower, but still above control, values. Additionally, corticotropin-releasing factor (CRF)-treated rats had decreased plasma testosterone levels. The subcutaneous administration of 0.075 or 0.75 nmol oCRF/h to intact rats for 7 d also resulted in elevations of both plasma ACTH and corticosterone levels comparable to those measured after a 24-h exposure to the releasing factor, as well as dose-related hypertrophy of the adrenals and increases in pituitary ACTH content. In these animals, CRF markedly inhibited luteinizing hormone (LH) (but not follicle-stimulating hormone [FSH] ), testosterone, and PRL secretion and decreased seminal vesicle weights. All the effects of CRF were mimicked by exogenously administered ACTH. By contrast, with the exception of FSH secretion, which was slightly elevated by CRF, neither CRF nor ACTH were able to significantly modify reproductive parameters in adrenalectomized animals, which suggests that the elevation of circulating levels of adrenal steroids induced by peripherally administered CRF represents major mediators of CRF-induced inhibition of fertility. These results indicate that in the rat, the continuous stimulation of the pituitary-adrenal axis by peripherally administered CRF causes some degree of desensitization of the pituitary-adrenal axis, but is still accompanied by persistent elevations of the circulating levels of both ACTH and corticosteroids. The increased secretion of adrenal steroids by CRF-treated rats is believed to participate in the disruption of reproductive parameters observed in these rats.
机译：在成年雄性大鼠中测量了持续暴露于绵羊促肾上腺皮质激素释放因子（oCRF）的影响。在24小时内向完整大鼠静脉内输注0.75 nmol oCRF / h，在释放因子给药的前90分钟出现ACTH和皮质酮分泌峰值，然后降低至更低，但价值仍然超出控制。此外，促肾上腺皮质激素释放因子（CRF）治疗的大鼠血浆睾丸激素水平降低。向完整大鼠皮下给药0.075或0.75 nmol oCRF / h达7天，其血浆血浆促肾上腺皮质激素和皮质类固醇水平的升高也与暴露于释放因子24小时以及剂量相关性肥大时的升高相当肾上腺皮质激素和垂体ACTH含量增加。在这些动物中，CRF显着抑制了促黄体生成激素（LH）（但不抑制促卵泡激素[FSH]），睾丸激素和PRL分泌，并降低了精囊重量。外用ACTH可模拟CRF的所有作用。相比之下，除了CRF使FSH分泌略微增加外，CRF和ACTH均不能显着改变肾上腺切除动物的生殖参数，这表明外周给药CRF引起的肾上腺类固醇循环水平升高代表了主要CRF诱导的生育抑制因子。这些结果表明，在大鼠中，外周给予CRF连续刺激垂体-肾上腺轴会导致垂体-肾上腺轴某种程度的脱敏，但仍伴随ACTH和皮质类固醇循环水平的持续升高。据信用CRF治疗的大鼠增加的肾上腺类固醇分泌参与了在这些大鼠中观察到的生殖参数的破坏。

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