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Is AJCC/UICC Staging Still Appropriate for Head and Neck Cancers inDeveloping Countries?

机译:AJCC / UICC分期是否仍适合头颈癌发展中国家?

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摘要

By 2030, 70% of cancers will occur in developing countries. Head and neck cancers areprimarily a developing world disease. While anatomical location and the extent of cancersare central to defining prognosis and staging, the American Joint Committee on Cancer(AJCC)/International Union Against Cancer (UICC) have incorporated nonanatomic factorsthat correlate with prognosis into staging (eg, p16 status of oropharyngeal cancers).However, 16 of 17 head and neck surgeons from 13 African countries cannot routinely testfor p16 status and hence can no longer apply AJCC/UICC staging to oropharyngeal cancer.While the AJCC/UICC should continue to refine staging that best reflects treatmentoutcomes and prognosis by incorporating new nonanatomical factors, they should also retainand refine anatomically based staging to serve the needs of clinicians and their patientsin resource-constrained settings. Not to do so would diminish their global relevance andin so doing also disadvantage most of the world’s cancer patients.
机译:到2030年,将有70%的癌症发生在发展中国家。头颈癌是主要是发展中国家的疾病。解剖位置和癌症范围对于确定预后和分期至关重要,美国癌症联合委员会(AJCC)/国际抗癌联盟(UICC)已纳入非解剖因素与分期的预后相关(例如,口咽癌的p16状态)。但是,来自13个非洲国家的17位头颈外科医师中有16位无法例行检查p16状态,因此不能再将AJCC / UICC分期应用于口咽癌。AJCC / UICC应该继续完善最能体现治疗方法的分期通过纳入新的非解剖学因素来评估结局和预后,还应保留并完善基于解剖的分期,以满足临床医生及其患者的需求在资源受限的设置中。不这样做会削弱他们的全球相关性,这样做也不利于世界上大多数癌症患者。

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