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首页> 美国卫生研究院文献>Sensors (Basel Switzerland) >A Compact Mid-Infrared Spectroscopy System for Healthcare Applications Based on a Wavelength-Swept Pulsed Quantum Cascade Laser
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A Compact Mid-Infrared Spectroscopy System for Healthcare Applications Based on a Wavelength-Swept Pulsed Quantum Cascade Laser

机译：基于波长扫描脉冲量子级联激光器的紧凑型中红外医疗系统

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摘要

A mid-infrared spectroscopic system using a high-speed wavelength-swept and pulsed quantum cascade laser (QCL) for healthcare applications such as blood glucose measurement is proposed. We developed an attenuated total reflection measurement system comprising the QCL with a micro-electromechanical system (MEMS)-scanning grating, hollow optical fibers, and InAsSb detector and tested its feasibility for healthcare applications. A continuous spectrum was obtained by integrating comb-shaped spectra, the timing of which was slightly shifted. As this method does not require complex calculations, absorption spectra are obtained in real-time. We found that the signal-to-noise ratio of the obtained spectrum had been improved by increasing the number of spectra that were integrated into the spectrum calculation. Accordingly, we succeeded in measuring the absorption spectrum of a 0.1% aqueous glucose solution. Furthermore, the absorption spectra of human lips were measured, and it was shown that estimation of blood glucose levels were possible using a model equation derived using a partial least squares regression analysis of the measured absorption spectra. The spectroscopic system based on the QCL with MEMS-scanning grating has the advantages of compactness and low cost over conventional Fourier transform infrared-based systems and common spectroscopic systems with a tunable QCL that has a relatively large, movable grating.
机译：提出了一种使用高速波长扫描和脉冲量子级联激光器（QCL）的中红外光谱系统，用于医疗保健应用，例如血糖测量。我们开发了一种衰减全反射测量系统，该系统包括带有微机电系统（MEMS）扫描光栅，空心光纤和InAsSb检测器的QCL，并测试了其在医疗保健领域的可行性。通过积分梳状光谱获得了连续光谱，其时间略有偏移。由于该方法不需要复杂的计算，因此可以实时获得吸收光谱。我们发现，通过增加集成到光谱计算中的光谱数量，可以改善所获得光谱的信噪比。因此，我们成功地测量了0.1％葡萄糖水溶液的吸收光谱。此外，测量了人的嘴唇的吸收光谱，并且表明可以使用模型方程来估计血糖水平，该模型方程是通过对所测量的吸收光谱进行偏最小二乘回归分析而得出的。基于QCL和MEMS扫描光栅的光谱系统与传统的基于傅立叶变换红外的系统和带有可调QCL的普通光谱系统相比具有紧凑和低成本的优点，该QCL具有相对较大的可移动光栅。

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