• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Inhalations with Brine Solution from the ‘Wieliczka’ Salt Mine Diminish Airway Hyperreactivity and Inflammation in a Murine Model of Non-Atopic Asthma
【2h】

Inhalations with Brine Solution from the ‘Wieliczka’ Salt Mine Diminish Airway Hyperreactivity and Inflammation in a Murine Model of Non-Atopic Asthma

机译：在非特应性哮喘的小鼠模型中从维利奇卡盐矿吸入盐水可减少气道高反应性和炎症

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Inhalations with brine solutions are old but underestimated add-ons to pharmacological treatments of inflammatory lung diseases. Although widely used, not all features underlying their action on the respiratory system have been explored. The aim of the present study was to elucidate the mechanism of the beneficial action of inhalations of brine solution from the ‘Wieliczka’ Salt Mine, a Polish health resort, in a murine model of non-atopic asthma. Asthma was induced in BALB/c mice by skin sensitization with dinitrofluorobenzene followed by an intratracheal challenge of cognate hapten. All animals underwent 12 inhalation sessions with brine solution, pure water or physiological saline. Control mice were not inhaled. We found that brine inhalations reduced, as compared to non-inhaled mice, the typical asthma-related symptoms, like airway hyperreactivity (AHR), the infiltration of pro-inflammatory cells into the bronchial tree, and the inflammation of the airways at the level of pro-inflammatory cytokines IL-1α, IL-1β and IL-6. The level of the anti-inflammatory IL-10 was elevated in brine-inhaled mice. Inhalations with pure water increased AHR, whereas saline had no influence, either on AHR or cytokine concentrations. These observations indicate that inhalations with a brine solution from the ‘Wieliczka’ Salt Mine diminish the asthma-related symptoms, mostly by reducing the inflammatory status and by decreasing AHR.
机译：盐溶液吸入是古老的，但被低估了炎症性肺疾病的药物治疗。尽管已被广泛使用，但尚未探究其作用于呼吸系统的所有功能。本研究的目的是阐明在非特应性哮喘的小鼠模型中，从波兰“疗养胜地”维利奇卡盐矿吸入盐溶液的有益作用机理。在BALB / c小鼠中，通过用二硝基氟苯进行皮肤致敏，然后气管内进行同源半抗原攻击，可诱发哮喘。所有动物均接受盐水溶液，纯净水或生理盐水的12次吸入。没有吸入对照小鼠。我们发现，与未吸入小鼠相比，盐水吸入减少了与哮喘相关的典型症状，例如气道反应过度（AHR），促炎细胞向支气管树的浸润以及该水平的气道炎症促炎细胞因子IL-1α，IL-1β和IL-6的表达。在吸入盐水的小鼠中，抗炎性IL-10的水平升高。用纯水吸入会增加AHR，而盐水对AHR或细胞因子浓度没有影响。这些观察结果表明，从“维利奇卡”盐矿吸入盐水溶液可以减轻与哮喘有关的症状，这主要是通过降低炎症状态和降低AHR来实现的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号