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首页> 美国卫生研究院文献>Medical Sciences >Atmospheric Pollution and Thyroid Function of Pregnant Women in Athens Greece: A Pilot Study
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Atmospheric Pollution and Thyroid Function of Pregnant Women in Athens Greece: A Pilot Study

机译：雅典希腊孕妇的大气污染和甲状腺功能的初步研究

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Exposure to air pollution and, in particular, to nitrogen dioxide (NO ) or particulate pollutants less than 2.5 μm (PM2.5) or 10 μm (PM10) in diameter has been linked to thyroid (dys)function in pregnant women. We hypothesized that there may be a dose—effect relationship between air pollutants and thyroid function parameters. We retrospectively evaluated thyrotropin (TSH) in 293 women, NO , PM2.5 and PM10 levels in Athens. All the women were diagnosed with hypothyroidism for the first time during their pregnancy. Exposure to air pollution for each woman was considered according to her place of residence. Statistical analysis of age, pregnancy weight change, and air pollutants versus TSH was performed with ordinary least squares regression (OLS-R) and quantile regression (Q-R). A positive correlation for logTSH and PM2.5( = +0.13, = 0.02) was found, using OLS-R. Further analysis with Q-R showed that each incremental unit increase (for the 10th to the 90th response quantile) in PM2.5 increased logTSH(±SE) between +0.029 (0.001) to +0.025 (0.001) mIU/L ( < 0.01). The other parameters and pollutants (PM10 and NO ) had no significant effect on TSH. Our results indeed show a dose—response relationship between PM2.5 and TSH. The mechanisms involved in the pathophysiological effects of atmospheric pollutants, in particular PM2.5, are being investigated.
机译：暴露于空气污染中，尤其是暴露于直径小于2.5μm（PM2.5）或直径小于10μm（PM10）的颗粒污染物与孕妇的甲状腺功能异常有关。我们假设空气污染物和甲状腺功能参数之间可能存在剂量效应关系。我们回顾性评估了293名妇女的促甲状腺激素（TSH），雅典的NO，PM2.5和PM10水平。所有妇女在怀孕期间首次被诊断出甲状腺功能减退。根据每个妇女的居住地，考虑每个妇女的空气污染暴露程度。使用普通最小二乘回归（OLS-R）和分位数回归（Q-R）对年龄，孕妇体重变化和空气污染物与TSH的关系进行统计分析。使用OLS-R，发现logTSH和PM2.5呈正相关（= + 0.13，= 0.02）。使用Q-R进行的进一步分析表明，PM2.5中的每个增量单位增加（对于第10至第90个响应分位数）在+0.029（0.001）至+0.025（0.001）mIU / L（<0.01）之间增加logTSH（±SE）。其他参数和污染物（PM10和NO）对TSH的影响不明显。我们的结果确实显示了PM2.5与TSH之间的剂量反应关系。正在研究涉及大气污染物（尤其是PM2.5）的病理生理效应的机制。

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