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Evaluation of Varicella Immunity during Pregnancy in Apulia Region Southern Italy

机译：意大利南部普利亚地区妊娠期间水痘免疫的评估

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摘要

Varicella is a highly contagious, infectious disease caused by the varicella-zoster virus. Those at higher risk of severe complications are immunocompromised individuals, adults, non-immune pregnant women, and newborns. According to the gestational time, when varicella-zoster virus infection is acquired during pregnancy, serious complications can potentially occur for both the woman and the fetus. The present study was conducted to assess the profile of varicella susceptibility in pregnant women in Apulia, a large region in Southern Italy, from 2016 to 2019. The data showed that pregnant women between the age of 15–24 and 40–49 years, the youngest and the oldest, respectively, are the most protected against varicella-zoster virus infection, exceeding the prevalence rate of 90%. Conversely, pregnant women between the age of 25 and 34 years seem to be the most vulnerable and the most at risk for acquiring varicella-zoster virus infection during pregnancy. Analysis of the immunity status against varicella should be introduced as a screening test before pregnancy, together with a strategic vaccination campaign targeting non-immune women of childbearing age, in order to reduce the risk of congenital and perinatal varicella.
机译：水痘是由水痘带状疱疹病毒引起的高度传染性传染病。发生严重并发症的风险较高的人是免疫力低下的个体，成人，非免疫孕妇和新生儿。根据妊娠时间，在怀孕期间感染水痘-带状疱疹病毒时，妇女和胎儿都可能发生严重的并发症。本研究旨在评估2016年至2019年意大利南部一个大区域普利亚的孕妇水痘易感性。数据显示，15-24岁至40-49岁之间的孕妇最年轻和最年长的人对水痘带状疱疹病毒感染的保护最强，超过90％的患病率。相反，年龄在25至34岁之间的孕妇似乎是最易受伤害的，并且在怀孕期间最易感染水痘带状疱疹病毒。应将针对水痘的免疫状态分析作为怀孕前的筛查测试，并针对未生育年龄的非免疫妇女进行战略性疫苗接种运动，以降低先天性和围产期水痘的风险。

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