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首页> 美国卫生研究院文献>Antioxidants >In vitro Antioxidant Anti-inflammatory Anti-metabolic Syndrome Antimicrobial and Anticancer Effect of Phenolic Acids Isolated from Fresh Lovage Leaves Levisticum officinale Koch Elicited with Jasmonic Acid and Yeast Extract
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In vitro Antioxidant Anti-inflammatory Anti-metabolic Syndrome Antimicrobial and Anticancer Effect of Phenolic Acids Isolated from Fresh Lovage Leaves Levisticum officinale Koch Elicited with Jasmonic Acid and Yeast Extract

机译：茉莉酸和酵母提取物提取的新鲜鲜叶Levisticum officinale Koch中的酚酸的体外抗氧化抗炎抗代谢综合征抗菌和抗癌作用

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摘要

Lovage seedlings were elicited with jasmonic acid (JA) and yeast extract (YE) to induce the synthesis of biologically active compounds. A simulated digestion process was carried out to determine the potential bioavailability of phenolic acids. Buffer extracts were prepared for comparison. The ability to neutralize ABTS radicals was higher in all samples after the in vitro digestion, compared to that in the buffer extracts. However, the elicitation resulted in a significant increase only in the value of the reduction power of the potentially bioavailable fraction of phenolic acids. The effect of the elicitation on the activity of the potentially bioavailable fraction of phenolic acids towards the enzymes involved in the pathogenesis of the metabolic syndrome, i.e., ACE, lipase, amylase, and glucosidase, was analyzed as well. The in vitro digestion caused a significant increase in the ability to inhibit the activity of these enzymes; moreover, the inhibitory activity against alpha-amylase was revealed only after the digestion process. The potential anti-inflammatory effect of the analyzed extracts was defined as the ability to inhibit key pro-inflammatory enzymes, i.e., lipoxygenase and cyclooxygenase 2. The buffer extracts from the YE-elicited lovage inhibited the LOX and COX-2 activity more effectively than the extracts from the control plants. A significant increase in the anti-inflammatory and antimicrobial properties was noted after the simulated digestion.
机译：茉莉酸（JA）和酵母提取物（YE）引发独活苗，以诱导生物活性化合物的合成。进行了模拟消化过程，以确定酚酸的潜在生物利用度。制备缓冲液提取物用于比较。与缓冲液提取物中的样品相比，体外消化后所有样品中和ABTS自由基的能力更高。然而，引发仅导致酚酸的潜在生物利用级分的还原能力的值显着增加。还分析了引发对酚酸潜在的生物利用级分对参与代谢综合症发病机理的酶（ACE，脂肪酶，淀粉酶和葡糖苷酶）活性的影响。体外消化导致抑制这些酶活性的能力显着增加。此外，仅在消化过程之后才显示出对α-淀粉酶的抑制活性。分析提取物的潜在抗炎作用定义为抑制关键促炎酶（脂氧合酶和环加氧酶2）的能力。从YE引发的独活菌中提取的缓冲液提取物比LOX和COX-2活性更有效地抑制了LOX和COX-2的活性。对照植物的提取物。在模拟消化后，抗炎和抗菌性能显着提高。

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