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首页> 美国卫生研究院文献>EFSA Journal >Safety and efficacy of Avatec® 150G (lasalocid A sodium) as a feed additive for chickens for fattening and chickens reared for laying
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Safety and efficacy of Avatec® 150G (lasalocid A sodium) as a feed additive for chickens for fattening and chickens reared for laying

机译：AVATEC®150G（Lasalocid A钠）作为鸡饲料饲喂的鸡饲料添加剂的安全性和有效性

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摘要

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( ) was asked to deliver a scientific opinion on the safety and efficacy of Avatec 150G (lasalocid A sodium) for chickens for fattening and chickens reared for laying. In 2017, the Panel was not able to conclude on a safe dose for chickens for fattening and chickens reared for laying and no conclusion could be drawn on the anticoccidial efficacy of the additive at the lowest proposed used level (75 mg lasalocid A sodium/kg feed) in these species. In the present assessment, the applicant submitted new tolerance and efficacy studies in chickens for fattening to address the concerns identified by the Panel in its former opinion. In addition, the applicant proposed to decrease the maximum of the dose range from 125 to 100 mg lasalocid A sodium/kg complete feed. Based on the additional information, the Panel concludes that no safe level of lasalocid A sodium from Avatec 150G in feed for chickens for fattening can be identified. The Panel is not in the position to conclude on the coccidiostatic efficacy of Avatec 150G for chickens for fattening at the lowest proposed dose level of 75 mg lasalocid A sodium/kg complete feed due to the insufficient number of studies with positive results. The conclusions are extended to chickens reared for laying.
机译：遵循欧盟委员会的请求后，动物饲料（）中使用的添加剂和产品或物质小组被要求提供对AVATEC 150G（Lasalocid A Sodium）的安全性和疗效进行肥胖和鸡饲养的鸡的安全性和疗效铺设。 2017年，小组无法在安全剂量的情况下得出结论，用于饲养饲养的肥胖，并且无法在最低提出的使用水平下对添加剂的反痛效果（75毫克达塞亚甲钠/千克饲料）在这些物种中。在目前的评估中，申请人提出了鸡的新耐受性和疗效研究，以解决小组在其前意见中确定的问题。此外，申请人提出将剂量范围的最大值降低至100mg Lasalocid钠/ kg完整饲料。基于附加信息，小组得出结论，可以鉴定任何安全水平的达塞核苷酸，可以从AVATEC 150G中喂食鸡的饲料中的鸡饲料。该小组未能达到AVATEC 150G的鸡菌的可团静态疗效，以便在最低提出的剂量水平为75毫克升塞核苷酸的最低提出剂量水平，由于具有阳性结果的研究数量不足，因此钠/千克完全饲料。结论延伸到饲养的鸡以铺设。

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