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Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances)

机译：植物保护产品的科学舆论及其残留物（PPR面板）对三嗪胺的基因毒性潜力（几种磺酰脲类活性物质共同的代谢物）

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The Panel received a mandate from the European Commission to assess the genotoxic potential of triazine amine based on available information submitted by the applicants. Available information includes experimental genotoxicity data on triazine amine, Quantitative Structure–Activity Relationship ( ) analysis and read across with structurally similar compounds. Based on the overall weight of evidence, the Panel, in agreement with the cross‐cutting Working Group Genotoxicity, concluded that there is no concern for the potential of triazine amine to induce gene mutations and clastogenicity; however, the potential to induce aneugenicity was not adequately investigated. For a conclusion, an micronucleus assay performed with triazine amine would be needed.

机译：该小组从欧洲委员会获得了授权，以评估基于申请人提交的可用信息的三嗪胺的遗传毒性潜力。可用信息包括关于三嗪胺，定量结构 - 活性关系（）分析的实验性遗传毒性数据，并在结构上类似的化合物读取。基于证据的总重量，小组同意与交叉切削工作组遗传毒性，得出结论认为，对于三嗪胺的潜力并不担心诱导基因突变和裂殖性的潜力;然而，没有充分研究诱导诱导鸟类的可能性。总之，需要用三嗪胺进行微核测定。

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期刊名称 EFSA Journal
作者
EFSA Panel on Plant Protection Products and their Residues (EFSA PPR Panel); Antonio F Hernandez‐Jerez; Paulien Adriaanse; Annette Aldrich; Philippe Berny; Tamara Coja; Sabine Duquesne; Anne Louise Gimsing; Marina Marinovich; Maurice Millet; Olavi Pelkonen; Silvia Pieper; Aaldrik Tiktak; Christopher J Topping; Ioanna Tzoulaki; Anneli Widenfalk; Gerrit Wolterink; Diane Benford; Gabriele Aquilina; Margherita Bignami; Claudia Bolognesi; Riccardo Crebelli; Rainer Guertler; Francesca Marcon; Elsa Nielsen; Josef Rudolf Schlatter; Christiane Vleminckx; Daniela Maurici; Juan Manuel Parra Morte;
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年(卷),期 2020(18),3
年度 2020
页码 -1
总页数 24
原文格式 PDF
正文语种
中图分类
关键词
‐A4098;

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外文文献
专利

1. Scientific Opinion of the Scientific Panel?on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances) [J] . Antonio F Hernandez‐Jerez, Paulien Adriaanse, Annette Aldrich, EFSA Journal . 2020,第3期

机译：科学小组的科学意见？在植物保护产品及其残留物（PPR面板）对三嗪胺的基因毒性潜力（几种磺酰脲类活性物质共同的代谢物）
2. Statement of the PPR Panel?on a framework for conducting the environmental exposure and risk assessment for transition metals when used as active substances in plant protection products (PPP) [J] . Antonio Hernandez‐Jerez, Paulien Adriaanse, Annette Aldrich, EFSA Journal . 2021,第3期

机译：PPR面板的陈述？在用作植物保护产品中的活性物质（PPP）中，对过渡金属进行环境暴露和过渡金属风险评估的框架
3. Outcome of the Public Consultation on the draft statement of the PPR Panel on a framework for conducting the environmental exposure and risk assessment for transition metals when used as active substances in plant protection products (PPP) [J] . Silvia Pieper, Annette Aldrich, Philippe Berny, EFSA supporting publications . 2021,第3期

机译：关于在植物保护产品中作为活性物质（PPP）的活性物质，对PPR小组关于开展环境暴露和风险评估的框架的框架上的公众磋商的结果
4. A Theoretical and Scientific Evaluation of the Potential to Form Sulfonic Acid Esters in Mesylate Salt Drug Substances and Drug Products [C] . Alina Domin Turza, Christopher M. McGinley, Robert J. Baker, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：对甲磺酸盐药物物质和药品形成磺酸酯的潜力的理论和科学评价
5. Scientific Opinion of the PPR Panel on the follow‐up of the findings of the External Scientific Report ‘Literature review of epidemiological studies linking exposure to pesticides and health effects’ [O] . EFSA Panel on Plant Protection Products and their Residues (PPR), Colin Ockleford, Paulien Adriaanse, 2017

机译：PPR小组关于外部科学报告将农药暴露与健康影响联系起来的流行病学研究的文献综述的发现的后续行动的科学意见
6. Scientific Opinion addressing the state of the science on risk assessment of plant protection products for non-target arthropods: EFSA Panel on Plant Protection Products and their Residues (PPR) [O] . Aagaard, Alf, Brock, Theo, Capri, Ettore, 2015

机译：科学意见评估非目标节肢动物的植物保护产品：EFsa植物保护产品及其残留物小组（ppR）

Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances)

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