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Prevalence of the Puumala orthohantavirus Strains in the Pre-Kama Area of the Republic of Tatarstan Russia

机译:俄罗斯鞑靼斯坦共和国前哈玛地区的Puumala Orthantavirus菌株的患病率

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摘要

(PUUV) causes nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) commonly diagnosed in Europe. The majority of HFRS cases in the European part of Russia are diagnosed in the Volga Federal District, which includes the Republic of Tatarstan (RT). The current study aims to analyze the genetic variability of PUUV in Pre-Kama region of the RT bounded by the Volga, Kama, and Vyatka rivers. In 2017, bank voles were caught in seven isolated forest traps in the Pre-Kama region and for the 26 PUUV-positive samples, the partial small (S), medium (M), and large (L) genome segment sequences were obtained and analyzed. It was determined that all identified PUUV strains belong to the Russian (RUS) genetic lineage; however, the genetic distance between strains is not directly correlated with the geographical distance between bank vole populations. One of the identified strains has S and L segments produced from one parental strain, while the M segment was supplied by another, suggesting that this strain could be the reassortant. We suggest that the revealed pattern of the PUUV strains distribution could be the result of a series of successive multidirectional migratory flows of the bank voles to the Pre-Kama region in the postglacial period.
机译:(PUUV)导致肾病血液肿(NE),一种温和形式的出血热,肾综合征(HFRs)常见于欧洲。俄罗斯欧洲部分的大多数HFR案件被诊断为伏尔加联邦区,其中包括鞑靼斯坦共和国(RT)。目前的研究旨在分析Volga,Kama和Vyatka Rivers的RT型RT的KAMA地区PUUV的遗传变异。 2017年,银行持续捕获在七野群地区的七个孤立的森林陷阱中,并且获得了26个PUUV阳性样品,部分小(S),中等(M)和大(L)基因组段序列分析。确定所有鉴定的PUUV菌株属于俄罗斯(RUS)遗传谱系;然而,应变之间的遗传距离与银座群体之间的地理距离不直接相关。其中一种鉴定的菌株具有由一种亲本菌株产生的S和L区段,而M个段由另一个父母提供,表明这种应变可以是重配剂。我们建议PUUV菌株分布的揭示模式可能是银行批量的一系列连续多向迁徙流到后爆炸期的结果。

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