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首页> 美国卫生研究院文献>Pathogens >Legionella Diversity and Spatiotemporal Variation in the Occurrence of Opportunistic Pathogens within a Large Building Water System
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Legionella Diversity and Spatiotemporal Variation in the Occurrence of Opportunistic Pathogens within a Large Building Water System

机译：Legionella多样性和时空变化在大型建筑水系统中机会主义病原体的发生

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Understanding survival mechanisms within building water systems (BWSs) is challenging due to varying engineering, operational, and water quality characteristics unique to each system. This study aimed to evaluate , mycobacteria, and free-living amoebae occurrence within a BWS over 18–28 months at six locations differing in plumbing material and potable water age, quality, and usage. A total of 114 bulk water and 57 biofilm samples were analyzed. culturability fluctuated seasonally with most culture-positive samples being collected during the winter compared to the spring, summer, and fall months. Positive and negative correlations between and occurrence and other physiochemical and microbial water quality parameters varied between location and sample types. Whole genome sequencing of 19 presumptive isolates, from four locations across three time points, identified nine isolates as serogroup (sg) 1 sequence-type (ST) 1; three as sg5 ST1950 and ST2037; six as ; and one as . Results showed the presence of a diverse population with consistent and sporadic occurrence at four and two locations, respectively. Viewed collectively with similar studies, this information will enable a better understanding of the engineering, operational, and water quality parameters supporting growth within BWSs.
机译：理解建筑物水系统内的生存机制（BWSS）由于各种系统独特的不同工程，操作和水质特征，挑战。本研究旨在评估，在六个地点在管道材料和饮用水时代，质量和用法不同的六个地点，在BWS内的六个地点进行评估，分枝杆菌和自由活的amoebae发生。分析了总共114个散装水和57个生物膜样品。与春季，夏季和秋季的冬季，冬季收集的大多数文化阳性样本季节性季节性季节性波动季节性态度波动。之间的正和负相关性 发生和其他物理化学和微生物水质参数在位置和样品类型之间变化。来自三个时间点的四个位置的全部基因组测序，从四个时间点，鉴定为血清组（SG）1序列类型（ST）1的九分离物;三为SG5 ST1950和ST2037;六是;和一个。结果表明，在四个和两个位置分别存在多元化的群体和散发性。通过类似的研究统称，这些信息将能够更好地了解支持BWSS内的增长的工程，操作和水质参数。

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