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首页> 美国卫生研究院文献>Marine Drugs >De novo Transcriptome of the Non-saxitoxin Producing Alexandrium tamutum Reveals New Insights on Harmful Dinoflagellates
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De novo Transcriptome of the Non-saxitoxin Producing Alexandrium tamutum Reveals New Insights on Harmful Dinoflagellates

机译：亚克萨里蓟蛋白的非撒克西蛋白的德诺转录组揭示了对有害恐龙的新见解

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Many dinoflagellates species, especially of the genus, produce a series of toxins with tremendous impacts on human and environmental health, and tourism economies. was discovered for the first time in the Gulf of Naples, and it is not known to produce saxitoxins. However, a clone of from the same Gulf showed copepod reproduction impairment and antiproliferative activity. In this study, the full transcriptome of the dinoflagellate is presented in both control and phosphate starvation conditions. RNA-seq approach was used for in silico identification of transcripts that can be involved in the synthesis of toxic compounds. Phosphate starvation was selected because it is known to induce toxin production for other spp. Results showed the presence of three transcripts related to saxitoxin synthesis (sxtA, sxtG and sxtU), and others potentially related to the synthesis of additional toxic compounds (e.g., 44 transcripts annotated as “polyketide synthase”). These data suggest that even if this clone does not produce saxitoxins, it has the potential to produce toxic metabolites, in line with the previously observed activity. These data give new insights into toxic microalgae, toxin production and their potential applications for the treatment of human pathologies.
机译：许多Dinoflagellates种类，尤其是属属，产生一系列毒素，对人类和环境健康以及旅游经济体产生巨大影响。在那不勒斯湾第一次发现了，并且不知道苏克西毒素不知道。然而，来自同一海湾的克隆显示桡足繁殖障碍和抗增殖活性。在该研究中，indoflagelate的完整转录组在对照和磷酸盐饥饿条件下呈现。 RNA-SEQ方法用于硅鉴定，可参与毒性化合物的合成。选择磷酸盐饥饿，因为已知诱导其他SPP的毒素产生。结果表明存在与萨克替毒素合成（SXTA，SXTG和SXTU相关的三种转录物，以及与所述额外毒性化合物的合成有关的其他转录物（例如，44种转录物作为“聚酮合成酶”）。这些数据表明，即使该克隆不产生萨克替毒素，它也有可能产生有毒代谢物，与先前观察到的活性。这些数据对有毒的微藻，毒素生产及其潜在应用提供了新的洞察力，用于治疗人类病理学。

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