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首页> 美国卫生研究院文献>Nanomaterials >The Effects of In Vivo Exposure to Copper Oxide Nanoparticles on the Gut Microbiome Host Immunity and Susceptibility to a Bacterial Infection in Earthworms
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The Effects of In Vivo Exposure to Copper Oxide Nanoparticles on the Gut Microbiome Host Immunity and Susceptibility to a Bacterial Infection in Earthworms

机译：体内暴露于氧化铜氧化物纳米粒子对蚯蚓中细菌感染的肠道氧化物纳米粒子对氧化铜纳米粒子的影响

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摘要

Nanomaterials (NMs) can interact with the innate immunity of organisms. It remains, however, unclear whether these interactions can compromise the immune functioning of the host when faced with a disease threat. Co-exposure with pathogens is thus a powerful approach to assess the immuno-safety of NMs. In this paper, we studied the impacts of in vivo exposure to a biocidal NM on the gut microbiome, host immune responses, and susceptibility of the host to a bacterial challenge in an earthworm. were exposed to CuO-nanoparticles in soil for 28 days, after which the earthworms were challenged with the soil bacterium . Immune responses were monitored by measuring mRNA levels of known earthworm immune genes. Effects of treatments on the gut microbiome were also assessed to link microbiome changes to immune responses. Treatments caused a shift in the earthworm gut microbiome. Despite these effects, no impacts of treatment on the expression of earthworm immune markers were recorded. The methodological approach applied in this paper provides a useful framework for improved assessment of immuno-safety of NMs. In addition, we highlight the need to investigate time as a factor in earthworm immune responses to NM exposure.
机译：纳米材料（NMS）可以与生物体的先天免疫相互作用。然而，仍然尚不清楚这些相互作用是否会在面对疾病威胁时损害主体的免疫功能。因此，具有病原体的共同暴露是评估NMS免疫安全的强大方法。在本文中，我们研究了体内暴露于疾病微生物组，宿主免疫应答和宿主的易感性对蚯蚓中的细菌攻击的影响。暴露于土壤中的CuO-纳米颗粒28天，之后蚯蚓与土壤细菌攻击。通过测量已知的蚯蚓免疫基因的mRNA水平来监测免疫应答。还评估了治疗对肠道微生物组的影响，以将微生物组的变化与免疫反应进行链接。治疗导致蚯蚓肠道微生物组的偏移。尽管有这些效果，但记录了对蚯蚓免疫标志物的表达的影响。本文中应用的方法方法提供了一种有用的框架，可改善NMS免疫安全评估。此外，我们突出了对NM暴露的蚯蚓免疫应答的一个因素来研究时间。

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