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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Application of Mesenchymal Stem Cell Therapy and Inner Ear Regeneration for Hearing Loss: A Review
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Application of Mesenchymal Stem Cell Therapy and Inner Ear Regeneration for Hearing Loss: A Review

机译：间充质干细胞疗法和内耳再生在听力损失中的应用：综述

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Inner and middle ear disorders are the leading cause of hearing loss, and are said to be among the greatest risk factors of dementia. The use of regenerative medicine for the treatment of inner ear disorders may offer a potential alternative to cochlear implants for hearing recovery. In this paper, we reviewed recent research and clinical applications in middle and inner ear regeneration and cell therapy. Recently, the mechanism of inner ear regeneration has gradually been elucidated. “Inner ear stem cells,” which may be considered the precursors of various cells in the inner ear, have been discovered in the cochlea and vestibule. Research indicates that cells such as hair cells, neurons, and spiral ligaments may form promising targets for inner ear regenerative therapies by the transplantation of stem cells, including mesenchymal stem cells. In addition, it is necessary to develop tests for the clinical monitoring of cell transplantation. Real-time imaging techniques and hearing rehabilitation techniques are also being investigated, and cell therapy has found clinical application in cochlear implant techniques.
机译：内部和中耳紊乱是听力损失的主要原因，据说是痴呆症的最大风险因素之一。用于治疗内耳疾病的再生药物可以提供用于听力恢复的耳蜗植入物的潜在替代品。在本文中，我们审查了最近在中耳再生和细胞疗法中的研究和临床应用。最近，内耳再生机制逐渐被阐明。在耳蜗和前庭发现，可以被认为是内耳中各种细胞的前体的“内耳干细胞”。研究表明，诸如毛细胞，神经元和螺旋韧带的细胞可以通过干细胞移植的内耳再生疗法形成有希望的靶标，包括间充质干细胞。此外，有必要开发用于细胞移植的临床监测的测试。还研究了实时成像技术和听力康复技术，细胞疗法在耳蜗植入技术中发现了临床应用。

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