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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Retrospective Assessment of the Antigenic Similarity of Egg-Propagated and Cell Culture-Propagated Reference Influenza Viruses as Compared with Circulating Viruses across Influenza Seasons 2002–2003 to 2017–2018
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Retrospective Assessment of the Antigenic Similarity of Egg-Propagated and Cell Culture-Propagated Reference Influenza Viruses as Compared with Circulating Viruses across Influenza Seasons 2002–2003 to 2017–2018

机译：与2002-2003至2017-2018的流感季节的循环病毒相比回顾性评估蛋繁殖和细胞培养 - 繁殖的参考流感病毒的抗原相似性

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Suboptimal vaccine effectiveness against seasonal influenza is a significant public health concern, partly explained by antigenic differences between vaccine viruses and viruses circulating in the environment. Haemagglutinin mutations within vaccine viruses acquired during serial passage in eggs have been identified as a source of antigenic variation between vaccine and circulating viruses. This study retrospectively compared the antigenic similarity of circulating influenza isolates with egg- and cell-propagated reference viruses to assess any observable trends over a 16-year period. Using annual and interim reports published by the Worldwide Influenza Centre, London, for the 2002–2003 to 2017–2018 influenza seasons, we assessed the proportions of circulating viruses which showed antigenic similarity to reference viruses by season. Egg-propagated reference viruses were well matched against circulating viruses for A/H1N1 and B/Yamagata. However, A/H3N2 and B/Victoria cell-propagated reference viruses appeared to be more antigenically similar to circulating A/H3N2 and B/Victoria viruses than egg-propagated reference viruses. These data support the possibility that A/H3N2 and B/Victoria viruses are relatively more prone to egg-adaptive mutation. Cell-propagated A/H3N2 and B/Victoria reference viruses were more antigenically similar to circulating A/H3N2 and B/Victoria viruses over a 16-year period than were egg-propagated reference viruses.
机译：对季节性流感的次优疫苗有效性是一个重要的公共卫生问题，部分原因是疫苗病毒与环境中循环中的病毒之间的抗原差异解释。在鸡蛋中串联通道期间获得的疫苗病毒中的血凝素突变已被鉴定为疫苗和循环病毒之间的抗原变异源。本研究回顾性比较了循环流感分离株的抗原相似性与蛋细胞繁殖的参考病毒，以评估16年期间的任何可观察趋势。使用伦敦全球流感中心发布的年度和临时报告，2002-2003至2017-2018流感季节，我们评估了循环病毒的比例，这些病毒逐个季节表现出对参考病毒的抗原相似性。蛋繁殖的参考病毒与A / H1N1和B / Yamagata的循环病毒很好地匹配。然而，A / H3N2和B / VICKORIA细胞 - 繁殖的参考病毒似乎更抗原地类似于循环A / H3N2和B / VICKORIA病毒而不是卵繁殖的参考病毒。这些数据支持A / H3N2和B / VICTORIA病毒的可能性相对越容易发生蛋适应突变。细胞繁殖的A / H3N2和B / VERTORIA参考病毒更抗原地类似于在16年期间的循环A / H3N2和B / VICKIS病毒而不是卵繁殖的参考病毒。

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