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The effect of some natural antioxidants against cisplatin-induced neurotoxicity in rats: behavioral testing

机译：一些天然抗氧化剂对大鼠顺铂诱导的大鼠神经毒性的影响：行为测试

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摘要

Cisplatin (CP) is a common antineoplastic agent widely used to treat a broad spectrum of cancers. However, its usage for cancer treatment was restricted due to various side effects such as neurotoxicity, nephrotoxicity, hepatotoxicity and ototoxicity. Neurotoxicity in patients who have undergone a complete course of chemotherapy is clinically evident. CP administration caused problems in rats with memory and learning.

机译：顺铂（CP）是广泛用于治疗广谱癌症的常见抗肿瘤剂。然而，由于各种副作用，诸如神经毒性，肾毒性，肝毒性和耳毒性，因此其对癌症治疗的用法受到限制。经过完整的化疗疗程的患者的神经毒性在临床上是明显的。 CP管理导致了大鼠内存和学习的问题。

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期刊名称 Heliyon
作者
Mohamed A. Kandeil; Safaa B. Gomaa; Mohamed O. Mahmoud;
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作者单位

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年(卷),期 2020(6),8
年度 2020
页码 -1
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
Cisplatin; Thymoquinone; Geraniol; Neurotoxicity; Behavior test; Rats; Behavioral neuroscience; Oxidative stress; Antioxidant; Chemotherapy;

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1. Neuroprotective influence of sitagliptin against cisplatin-induced neurotoxicity, biochemical and behavioral alterations in Wistar rats [J] . Li Yuxin, Zheng Maoyong, Sah Sushil Kumar, Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2019,第1a2期

机译：SITAGLIPTIN对激滑铂诱导的神经毒性，生物化学和行为改变的神经保护作用
2. THE EFFECT OF ANTIOXIDANT CAFFEIC ACID PHENETHYL ESTER (CAPE) ON SOME ENZYME ACTIVITIES IN CISPLATIN-INDUCED NEUROTOXICITY IN RATS [J] . ?zyurt Birsen, Güle? Mukaddes, ?zyurt Hüseyin, European Journal of General Medicine . 2006,第4期

机译：抗氧化剂咖啡酸苯乙酯（CAPE）对CISPLATIN诱导的大鼠神经毒性的某些酶活性的影响
3. Antioxidants enhance the recovery of three cycles of bleomycin, etoposide, and cisplatin-induced testicular dysfunction, pituitary-testicular axis, and fertility in rats [J] . KilarkajeN., MousaA.M., Al-BaderM.M., Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society . 2013,第4期

机译：抗氧化剂可增强博来霉素，依托泊苷和顺铂诱导的大鼠睾丸功能障碍，垂体-睾丸轴和生育力三个周期的恢复
4. Comparative study on natural and synthetic antioxidants on thermo-oxidative aging of natural and synthetic rubber vulcanizates [C] . N.H.H. Shuhaimi, N. Othman, H. Ismail Asia Pacific Rubber Conference . 2014

机译：天然合成抗氧化剂对天然合成橡胶硫化的热氧化抗氧化剂的比较研究
5. Importance of methionine 35 in free radical -associated mechanisms of Alzheimer's amyloid beta -peptide neurotoxicity, and experimental rationale for the use of antioxidants as therapeutic intervention in Alzheimer's disease [D] . Kanski, Jaroslaw 2001

机译：蛋氨酸35在阿尔茨海默氏症淀粉样β肽神经毒性的自由基相关机制中的重要性，以及使用抗氧化剂作为阿尔茨海默氏病治疗干预的实验依据
6. Erratum to: Synthetic and natural antioxidants attenuate cisplatin-induced vomiting [O] . Javaid Alam, Fazal Subhan, Ihsan Ullah, 2017

机译：勘误至：合成抗氧化剂和天然抗氧化剂可减轻顺铂引起的呕吐
7. Erratum to: Synthetic and natural antioxidants attenuate cisplatin-induced vomiting [O] . 2017

机译：勘误至：合成抗氧化剂和天然抗氧化剂可减轻顺铂引起的呕吐

The effect of some natural antioxidants against cisplatin-induced neurotoxicity in rats: behavioral testing

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