Understanding the roles of stress granule during chemotherapy for patients with malignant tumors

机译：了解对恶性肿瘤患者化疗过程中应激颗粒的作用

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摘要

The assembly of stress granules (SGs) is a conserved mechanism to regulate protein synthesis under cell stress, where the translation of global protein is silenced and selective protein synthesis for survival maintains. SG formation confers survival advantages and chemotherapeutic resistance to malignant cells. Targeting SG assembly may represent a potential treatment strategy to overcome the primary and acquired chemotherapeutic resistance and enhance curative effect. We conduct a comprehensive review of the published literatures focusing on the drugs that potentially induce SGs and the related mechanism, retrospect the relationship between SGs and drug resistance related proteins, illuminate the regulated pathways and potential targets for SG assembly, and discuss future directions of overcoming the resistance to chemotherapy.

机译：应激颗粒组件（SGS）是一种保守的机制，用于调节细胞应激下的蛋白质合成，其中全局蛋白质的翻译是沉默的和选择性蛋白质合成的存活。 SG形成赋予恶性细胞的生存优势和化学治疗抗性。靶向SG组件可以代表潜在的治疗策略，以克服初级和获得的化学治疗抗性和增强疗效。我们对专注于潜在诱导SGS和相关机制的药物的出版文献进行了全面的审查，回顾了SGS和耐药性相关蛋白质之间的关系，照亮了调节的途径和SG组装的潜在目标，并讨论了未来的克服方向抗化疗抗性。

著录项

期刊名称 American Journal of Cancer Research
作者
Yuting Zhan; Haihua Wang; Yue Ning; Hongmei Zheng; Sile Liu; Yang Yang; Ming Zhou; Songqing Fan;
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作者单位

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年(卷),期 2020(10),8
年度 2020
页码 -1
总页数 16
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Stress granule; G3BP1; chemotherapy; chemoresistance; mTOR signaling;

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专利

1. Understanding the roles of stress granule during chemotherapy for patients with malignant tumors [J] . Yuting Zhan, Haihua Wang, Yue Ning, American Journal of Cancer Research . 2020,第8期

机译：理解应激颗粒在化疗中对恶性肿瘤患者的作用
2. Viable malignant cells after primary chemotherapy for disseminated nonseminomatous germ cell tumors: prognostic factors and role of postsurgery chemotherapy--results from an international study group. [J] . Fizazi K, Tjulandin S, Salvioni R, Journal of Clinical Oncology . 2001,第10期

机译：一项国际研究小组的研究结果显示，原发性化疗后弥漫性非精原细胞性生殖细胞肿瘤的存活恶性细胞：预后因素和术后化疗的作用。
3. Comparison of modified Response Evaluation Criteria in Solid Tumors, European Organization for Research and Treatment of Cancer criteria, and PET Response Criteria in Solid Tumors for evaluation of tumor response to chemotherapy and prognosis prediction in patients with unresectable malignant pleural mesothelioma [J] . Kitajima Kazuhiro, Maruyama Mitsunari, Minami Toshiyuki, Nuclear Medicine Communications . 2020,第8期

机译：实体肿瘤修饰响应评价标准的比较，欧洲癌症标准的研究和治疗组织，以及实体肿瘤的宠物响应标准，评价肿瘤反应与不可切除恶性胸膜间皮瘤患者的肿瘤反应及预后预测
4. Progress in Chemotherapy of Malignant Bone Tumors [C] . Rui Jiang, Ziyan Zhang, Han Wu, International Conference on Advances in Social Science and Sustainable Development . 2018

机译：恶性骨肿瘤化疗的进展
5. An economic analysis of the addition of bevacizumab to standard chemotherapy in patients with malignant pleural mesothelioma. [D] . Malacan, Jean. 2016

机译：恶性胸膜间皮瘤患者在标准化疗中加用贝伐单抗的经济分析。
6. Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins? [O] . Anaïs Aulas, Pascal Finetti, Shawn M. Lyons, 2020

机译：重新审视实体肿瘤预后的压力概念：应激颗粒蛋白的作用？
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Understanding the roles of stress granule during chemotherapy for patients with malignant tumors

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