Antibioticresistance is a growing health crisis, as the rate of antibiotic resistanceis developing more rapidly than the approval of new antibiotic therapies.1−3 Even more troubling is the emergence of multi-drug-resistant pathogensand “super bugs” that are resistant to many common antibioticsused in the clinic.4 To address this healthcrisis, new antibiotics that have unique targets are needed, so thata strain of bacteria that is resistant to one antibiotic will likelybe sensitive to a novel antibiotic treatment. In this issue of ACS Central Science, Hübner and colleagues uncovera new antibiotic mechanism of action that could meet this demand.5
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