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首页> 美国卫生研究院文献>Aging (Albany NY) >The therapeutic significance of the novel photodynamic material TPE-IQ-2O in tumors
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The therapeutic significance of the novel photodynamic material TPE-IQ-2O in tumors

机译：新型光动力材料TPE-IQ-2o在肿瘤中的治疗意义

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摘要

Combination therapies based on photodynamic therapy (PDT) have received much attention in various cancers due to their strong therapeutic effects. Here, we aimed to explore the safety and effectiveness of a new mitochondria-targeting photodynamic material, TPE-IQ-2O, in combination therapies (combined with surgery or immunotherapy). The safety and effectiveness of TPE-IQ-2O PDT were verified with cytotoxicity evaluation in vitro and a zebrafish xenograft model in vivo, respectively. The effectiveness of TPE-IQ-2O PDT combined with surgery or immune checkpoint inhibitors (ICIs) was verified in tumor-bearing mice. Small animal in vivo imaging, immunohistochemistry, and flow cytometry were used to determine the underlying mechanism. TPE-IQ-2O PDT can not only reduce tumor recurrence in surgical treatment but also effectively improve the response to ICIs in immunotherapy without obvious toxicity. It was also found to ameliorate the immunosuppressive tumor microenvironment and promote the antitumor immunity induced by ICIs by increasing CD8+ tumor-infiltrating lymphocyte accumulation. Thus, TPE-IQ-2O PDT is a safe and effective antitumor therapy that can be combined with surgery or immunotherapy.
机译：由于其强烈的治疗效果，基于光动力疗法（PDT）的组合疗法在各种癌症中受到了很多关注。在这里，我们旨在探讨新型线粒体靶向光动力学材料TPE-IQ-2O的安全性和有效性，组合治疗（与手术或免疫疗法结合）。 TPE-IQ-2O PDT的安全性和有效性分别在体外进行细胞毒性评价和体内斑马鱼异种移植模型进行了验证。 TPE-IQ-2O PDT联合手术或免疫检查点抑制剂（ICIS）的有效性在携带肿瘤的小鼠中验证。体内成像，免疫组化和流式细胞术中的小动物用于确定下面的机制。 TPE-IQ-2O PDT不仅可以降低手术治疗中的肿瘤复发，而且还有效改善对ICIS在免疫疗法中对ICIS的反应，而无明显毒性。还发现，通过增加CD8 +肿瘤浸润淋巴细胞积累，还发现可改善免疫抑制肿瘤微环境并促进ICIS诱导的抗肿瘤免疫。因此，TPE-IQ-2O PDT是一种安全有效的抗肿瘤疗法，可与手术或免疫疗法组合。

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