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The Aqueous Extract of

机译：含水提取物

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The effects of sun exposure on the skin and specifically those related to pigmentation disorders are well known. It has recently been shown that blue light leads to the induction of oxidative stress and long-lasting pigmentation. The protective effect of an aqueous extract of Polypodium leucotomos (Fernblock®) is known. Our aim was to investigate the action mechanism of Fernblock® against pigmentation induced by blue light from digital devices. Human fibroblasts (HDF) and murine melanocytes (B16-F10) were exposed to artificial blue light (a 400–500 nm LED lamp). Cell viability, mitochondrial morphology, and the expression of the mitogen-activated protein kinase (MAPK) p38, known markers involved in the melanogenesis pathway, were evaluated. The activation of Opsin-3, a membrane protein sensitive to blue light that triggers the activation of the enzyme tyrosinase responsible for melanogenesis in melanocytes, was also analyzed. Our results demonstrated that pretreatment with Fernblock® prevents cell death, alteration of mitochondrial morphology, and phosphorylation of p38 in HDF exposed to blue light. In addition, Fernblock® significantly reduced the activation of Opsin-3 in melanocytes and the photo-oxidation of melanin, preventing its photodegradation. In sum, Fernblock® exerts beneficial effects against the detrimental impact of blue light from digital devices and could prevent early photoaging, while maintaining skin homeostasis.
机译：阳光暴露对皮肤的影响以及特异性与色素沉着疾病有关的影响是众所周知的。最近显示出蓝光导致诱导氧化应激和持久的色素沉着。已知聚吡吡吡核苷酸水提取物（Fernblock®）的保护作用是已知的。我们的目标是调查Fernblock®对来自数字设备的蓝光引起的色素沉着的动作机制。将人的成纤维细胞（HDF）和鼠黑色细胞（B16-F10）暴露于人造蓝光（400-500nm LED灯）。评估细胞活力，线粒体形态和丝裂剂活化蛋白激酶（MAPK）P38的表达，已知在丝素生成途径中涉及的已知标志物。还分析了OPSIN-3的激活，对蓝光敏感的膜蛋白敏感，触发负责在黑素细胞中对丝瓜生成的酶酪氨酸酶的激活，也是敏感的。我们的结果表明，使用Fernblock®预处理可防止细胞死亡，改变线粒体形态，并在暴露于蓝光下的HDF中P38的磷酸化。此外，Fernblock®显着降低了Melanocytes的Opsin-3的激活和黑色素的光氧化，防止了光降解。总而言之，Fernblock®对来自数字设备的蓝光的有害影响产生有益影响，并且可以防止早期的照片，同时保持皮肤稳态。

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