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Characteristics Management and Outcomes of Spondylodiscitis in Children: A Systematic Review

机译：儿童脊髓型肌炎的特征管理和结果：系统审查

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Spondylodiscitis (SD) is the concurrent infection of the intervertebral disc and the adjacent vertebral bodies. Currently, there is a substantial lack of structured reviews about this topic. The aim of this study was to systematically review the available literature in order to determine the main features of pediatric SD. A systematic search of MEDLINE database was performed, according to the PRISMA guideline recommendations. Clinical features, laboratory data, radiological signs, treatments strategies, and outcomes were summarized. Studies’ quality assessments were performed using the JBI Critical Appraisal Checklists. A total of 35 retrospective studies were analyzed and 340 children were identified. The most frequently affected age class was 0.5–4 years. The most affected site was the lumbar spine. The most commonly reported symptoms were back pain (37.97%) and refusal to walk/to stand/to sit (49.79%). The most frequently identified pathogen was Staphylococcus aureus (n = 33). The most used antibiotics were third generation cephalosporins. The intravenous therapy duration range was 1–25 weeks, the oral therapy duration range was 5 days–36 months. Surgery was used in 5.88% of children. In 29 cases clinical sequelae were documented. This study provides the main features of pediatric SD; it also emphasizes the significant gaps in the literature regarding this topic.
机译：椎间盘突出（SD）是椎间盘和邻近椎体的同时感染。目前，有关于这一主题的大量缺乏结构化评论。本研究的目的是系统地审查可用文献，以确定儿科SD的主要特征。根据PRISMA指南建议，执行了对MEDLINE数据库的系统搜索。总结了临床特征，实验室数据，放射性迹象，治疗策略和结果。使用JBI关键评估清单进行研究的质量评估。共分析了35项回顾性研究，并确定了340名儿童。最常见的年龄阶级为0.5-4岁。受影响最大的网站是腰椎。最常见的症状是背部疼痛（37.97％）并拒绝走路/抵抗/坐下（49.79％）。最常鉴定的病原体是金黄色葡萄球菌（n = 33）。最常用的抗生素是第三代头孢菌素。静脉治疗持续时间范围为1-25周，口腔治疗持续时间范围为5天 - 36个月。手术用于5.88％的儿童。在29例中记录了临床后遗症。本研究提供了儿科SD的主要特征;它还强调有关本主题的文献中的重大差距。

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