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首页> 美国卫生研究院文献>Bioactive Materials >Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing
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Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing

机译：聚二胺纳米粒子点缀食品口香糖水凝胶具有优异的抗菌活性和快速形状适应性加速细菌感染伤口愈合

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摘要

Most commonly used wound dressings have severe problems, such as an inability to adapt to wound shape or a lack of antibacterial capacity, affecting their ability to meet the requirements of clinical applications. Here, a nanocomposite hydrogel (XKP) is developed by introducing polydopamine nanoparticles (PDA NPs) into a food gum matrix (XK, consisting of xanthan gum and konjac glucomannan, both FDA-approved food thickening agents) for skin wound healing. In this system, the embedded PDA NPs not only interact with the food gum matrix to form a hydrogel with excellent mechanical strength, but also act as photothermal transduction agents to convert near-infrared laser radiation to heat, thereby triggering bacterial death. Moreover, the XKP hydrogel has high elasticity and tunable water content, enabling it to adapt to the shape of the wound and insulate it, providing a moist environment suitable for healing. In-vivo skin wound healing results clearly demonstrate that XKP can significantly accelerate the healing of wounds by reducing the inflammatory response and promoting vascular reconstruction. In summary, this strategy provides a simple and practical method to overcome the drawbacks of traditional wound dressings, and provides further options when choosing suitable wound healing materials for clinical applications.
机译：最常用的伤口敷料具有严重的问题，例如无法适应伤口形状或缺乏抗菌能力，影响其满足临床应用要求的能力。这里，通过将聚二胺纳米颗粒（PDA NPS）引入食品胶质基质（XK，由黄原胶和Konjac Glucomananan，FDA批准的食品增稠剂组成）来开发纳米复合材料水凝胶（XKP）用于皮肤伤口愈合。在该系统中，嵌入的PDA NP不仅与食品胶基质相互作用以形成具有优异机械强度的水凝胶，而且作为光热转导剂以将近红外激光辐射转换为热量，从而引发细菌死亡。此外，XKP水凝胶具有高弹性和可调谐含水量，使其适应伤口的形状并使其隔离，提供适合愈合的潮湿环境。体内皮肤伤口愈合结果清楚地表明，XKP通过降低炎症反应和促进血管重建来显着加速伤口的愈合。总之，该策略提供了一种简单实用的方法来克服传统伤口敷料的缺点，并在为临床应用选择合适的伤口愈合材料时提供进一步的选择。

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