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Engineering of tissue constructs using coaxial bioprinting

机译：同轴生物监测的组织构建工程

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Bioprinting is a rapidly developing technology for the precise design and manufacture of tissues in various biological systems or organs. Coaxial extrusion bioprinting, an emergent branch, has demonstrated a strong potential to enhance bioprinting's engineering versatility. Coaxial bioprinting assists in the fabrication of complex tissue constructs, by enabling concentric deposition of biomaterials. The fabricated tissue constructs started with simple, tubular vasculature but have been substantially developed to integrate complex cell composition and self-assembly, ECM patterning, controlled release, and multi-material gradient profiles. This review article begins with a brief overview of coaxial printing history, followed by an introduction of crucial engineering components. Afterward, we review the recent progress and untapped potential in each specific organ or biological system, and demonstrate how coaxial bioprinting facilitates the creation of tissue constructs. Ultimately, we conclude that this growing technology will contribute significantly to capabilities in the fields of in vitro modeling, pharmaceutical development, and clinical regenerative medicine.
机译：BioPlinting是一种迅速发展的技术，可用于各种生物系统或器官的组织的精确设计和制造。同轴挤出生物监测，一种紧急分支，已经表现出强大的潜力，以提高生物监测的工程多种能力。通过使生物材料同心沉积，同轴生物印刷器有助于制造复杂组织构建体。制造的组织构建体以简单，管状脉管系统开始，但已基本上开发成集成复杂的细胞组成和自组装，ECM图案化，控释和多重梯度型材。本篇综述文章始于同轴印刷历史的简要概述，其次是引入关键工程组件。之后，我们审查了每个特定器官或生物系统中最近的进展和未开发的潜力，并证明了同轴的生物监测如何促进组织构建体的创造。最终，我们得出结论，这种越来越多的技术将对体外建模，药物发育和临床再生医学领域的能力有显着贡献。

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