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首页> 美国卫生研究院文献>Bioactive Materials >Design of a biofluid-absorbing bioactive sandwich-structured Zn–Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing
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Design of a biofluid-absorbing bioactive sandwich-structured Zn–Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing

机译：生物流体吸收生物活性夹层的设计型Zn-Si Bioceramic复合伤口妊娠毛囊再生和皮肤烧伤伤口愈合

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摘要

The deep burn skin injures usually severely damage the dermis with the loss of hair follicle loss, which are difficult to regenerate. Furthermore, severe burns often accompanied with large amount of wound exudates making the wound moist, easily infected, and difficult to heal. Therefore, it is of great clinical significance to develop wound dressings to remove wound exudates and promote hair follicle regeneration. In this study, a sandwich-structured wound dressing (SWD) with Janus membrane property was fabricated by hot compression molding using hydrophilic zinc silicate bioceramics (Hardystonite, ZnCS) and hydrophobic polylactic acid (PLA). This unique organic/inorganic Janus membrane structure revealed excellent exudate absorption property and effectively created a dry wound environment. Meanwhile, the incorporation of ZnCS bioceramic particles endowed the dressing with the bioactivity to promote hair follicle regeneration and wound healing through the release of Zn2+ and SiO32− ions, and this bioactivity of the wound dressing is mainly attributed to the synergistic effect of Zn2+ and SiO32− to promote the recruitment, viability, and differentiation of hair follicle cells. Our study demonstrates that the utilization of the Janus membrane and synergistic effect of different type bioactive ions are effective approaches for the design of wound dressings for burn wound healing.
机译：随着毛囊损失的损失，深烧伤的皮肤损伤通常会严重损害真皮，这难以再生。此外，严重的烧伤通常伴随着大量的伤口渗出物，使伤口湿润，容易感染，难以愈合。因此，开发伤口敷料以去除伤口渗出物并促进毛发卵泡再生的临床意义。在本研究中，使用亲水锌硅酸盐生物陶瓷（Hardystonite，ZnC）和疏水聚乳酸（PLA）通过热压缩成型制造夹心结构卷绕敷料（SWD）。这种独特的有机/无机Janus膜结构显示出优异的渗出物吸收性能，有效地产生了干伤口环境。同时，ZnCs生物陶瓷颗粒的掺入赋予了通过释放Zn2 +和SiO32-离子的生物活性以促进毛发卵泡再生和伤口愈合，并且这种伤口敷料的生物活性主要归因于Zn2 +和SiO32的协同作用。 - 促进毛囊细胞的招生，活力和分化。我们的研究表明，Janus膜的利用和不同类型的生物活性离子的协同效应是用于烧伤伤口愈合的伤口敷料的有效方法。

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