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Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics Skin Disease Study and Environmental Skin Impact Analysis

机译：生物工程皮肤旨在作为药物药物皮肤病研究和环境皮肤影响分析的体外模型

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This review aims to be an update of Bioengineered Artificial Skin Substitutes (BASS) applications. At the first moment, they were created as an attempt to replace native skin grafts transplantation. Nowadays, these in vitro models have been increasing and widening their application areas, becoming important tools for research. This study is focus on the ability to design in vitro BASS which have been demonstrated to be appropriate to develop new products in the cosmetic and pharmacology industry. Allowing to go deeper into the skin disease research, and to analyze the effects provoked by environmental stressful agents. The importance of BASS to replace animal experimentation is also highlighted. Furthermore, the BASS validation parameters approved by the OECD (Organisation for Economic Co-operation and Development) are also analyzed. This report presents an overview of the skin models applicable to skin research along with their design methods. Finally, the potential and limitations of the currently available BASS to supply the demands for disease modeling and pharmaceutical screening are discussed.
机译：该审查旨在更新生物工程人工皮肤替代品（低音）应用。在第一时刻，他们被创造成试图取代本地皮肤移植移植。如今，这些体外模型一直在增加和扩大应用领域，成为研究的重要工具。本研究专注于设计体外低音的能力，这些贝斯已经被证明是适合于在化妆品和药理学行业开发新产品。允许深入进入皮肤病研究，并分析环境压力特性引起的效果。也强调了低音替代动物实验的重要性。此外，还分析了经合组织（经济合作和发展组织）批准的低音验证参数。本报告概述了适用于皮肤研究的皮肤模型以及其设计方法。最后，讨论了目前可用低音供应疾病建模需求和药物筛选的潜在和限制。

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