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Osmolality of Medications Administered in the Neonatal Intensive Care Unit

机译:在新生儿重症监护室中施用的药物渗透压

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摘要

The most recent recommendations regarding enteral feeding solutions for newborns state that they should have a maximum osmolality of 450 mOsm/kg (400 mOsm/L) and that the use of hyperosmolar feeding solutions may be a factor in the development of necrotizing enterocolitis.1,2 These recommendations are based on historical consensus,3 and there is little other evidence to guide this practice. For preterm newborns at risk of necrotizing enterocolitis, or infants at risk of osmotic diarrhea because of gastrointestinal abnormalities, enteral medications are often diluted in small amounts of breast milk or formula (usual osmolality about 300 mOsm/kg), both for ease of administration and to reduce the osmolar challenge of the medications. Unfortunately, for many compounded and commercially available oral liquid medications, published osmolality values are not available to clinicians to aid in assessing the osmolar load and the risks associated with enteral administration. The purpose of this study was to measure the osmolality of several proprietary and compounded medications commonly used in the neonatal intensive care unit.
机译:关于新生儿状态的肠内喂养解决方案的最新建议,它们应该具有450个MOSM / kg(400 mOSM / L)的最大渗透压液,并且使用Hypermolar饲养溶液的使用可能是恶作剧肠肠炎的发育中的一个因素。 2这些建议基于历史共识,3,几乎没有其他证据来指导这种做法。对于暴力肠结肠炎的风险预留新生儿,或由于胃肠道异常的渗透腹泻风险的婴儿,肠内药物通常以少量母乳或公式(通常是300 mOSM / kg)的少量稀释,以便于给药和减少药物的渗透挑战。遗憾的是,对于许多复合和市售的口服液体药物,临床医生没有出版的渗透性值,以帮助评估渗透载荷和与肠内给药相关的风险。本研究的目的是测量常用于新生儿重症监护病房的几种专有和复合药物的渗透压。

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