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首页> 美国卫生研究院文献>Cancers >HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma MCF7 and HeLa Cancer Cells
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HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma MCF7 and HeLa Cancer Cells

机译：HSPA2伴侣伴有助于维持人支气管上皮细胞的上皮表型但在支持非小细胞肺癌MCF7和HELA癌细胞的恶性特征方面具有非必要作用

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摘要

Heat shock proteins A (HSPA) are molecular chaperones that play a central role in the cellular protein quality control. One of them is HSPA2 which recently was indicated as a novel cancer-related protein due to its elevated expression in various tumors and reported prognostic significance. Several previous in vitro studies have shown significant role of HSPA2 in supporting cancer cells growth and invasiveness. Our data presented in this article contradict the current belief of the essential role of HSPA2 chaperone and show that HSPA2 is not crucial for maintenance of the malignant phenotype of lung, breast, and cervical cancer cells. Instead, we revealed HSPA2’s role in supporting clonogenic potential and adhesive ability of bronchial epithelial cells. Therefore, further research should concentrate on elucidating HSPA2 roles in epithelial cells.
机译：热休克蛋白A（HSPA）是在细胞蛋白质质量控​​制中起着中心作用的分子伴侣。其中一个是HSPA2由于其在各种肿瘤中的表达升高并报告了预后意义，最近被称为新的癌症相关蛋白质。以前的几种体外研究表明HSPA2在支持癌细胞生长和侵袭性方面的显着作用。我们本文提出的数据与HSPA2伴侣酮的基本作用相矛盾，表明HSPA2对维持肺癌，乳腺癌和宫颈癌细胞的恶性表型至关重要。相反，我们揭示了HSPA2在支持支气管上皮细胞的克隆源和粘合能力方面的作用。因此，进一步的研究应专注于阐明上皮细胞中的HSPA2作用。

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