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首页> 美国卫生研究院文献>Child Neurology Open >Fatal Acute Hemorrhagic Leukoencephalitis Following Immunization Against Human Papillomavirus in a 14-Year-Old Boy
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Fatal Acute Hemorrhagic Leukoencephalitis Following Immunization Against Human Papillomavirus in a 14-Year-Old Boy

机译：14岁男孩的人乳头瘤病毒免疫后致命的急性出血性白血病

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Human papilloma virus (HPV) is a prevalent pathogen whose persistent infection can lead to a variety of cancers. To protect against this threat, an HPV vaccine has been developed and is routinely administered to adolescents. The HPV vaccine has a reassuring safety profile, but reports have emerged of acute disseminated encephalomyelitis following its administration. Acute hemorrhagic leukoencephalitis (AHLE) is a severe inflammatory disease of the central nervous system and the most fulminant form of ADEM. We report a previously healthy 14-year-old boy who developed headache, fatigue, focal weakness, and confusion 3 weeks after receiving the HPV vaccine. Neuroimaging demonstrated multifocal demyelination. Despite treatment with high-dose steroids, his encephalopathy worsened. He developed severe cerebral edema and died of cerebral herniation. Postmortem histology revealed perivenular sleeves of tissue damage, myelin loss surrounding small parenchymal vessels, and diffuse hemorrhagic necrosis, consistent with AHLE. This is the first report of AHLE following HPV vaccination.
机译：人乳头瘤病毒（HPV）是一种普遍存在的病原体，其持续感染可能导致各种癌症。为了防范这种威胁，已经开发了HPV疫苗，并经常向青少年进行。 HPV疫苗具有令人放心的安全性剖面，但报告已经出现了其给药后急性播散的脑脊髓炎。急性出血性白细胞炎（AHLE）是中枢神经系统的严重炎症疾病和最令人兴奋的Adem形式。我们举报了一个以前健康的14岁男孩，在收到HPV疫苗后3周发育头痛，疲劳，焦点和混乱。神经影像上显示多灶性脱髓鞘。尽管用高剂量类固醇治疗，他的脑病恶化。他开发出严重的脑水肿并死于脑疝。后期组织学揭示了组织损伤，髓鞘损失周围的小实质血管，并弥漫性出血性坏死，与曝光一致。这是HPV疫苗接种后艾哈尔的第一报告。

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