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A review on the advancements in the development of vaccines to combat coronavirus disease 2019

机译：2019年对抗冠状病毒疫苗疫苗发展进步述评

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Coronavirus disease 2019 (COVID-19), the deadly disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a global pandemic that has severely affected lives and economies around the globe. The spread of this virus will be very difficult to contain if no vaccine is ready for implementation. This is because of the high human-to-human transmission rate of this virus and the fact that the virus is in the community spread stage. As of 31st August 2020, 25.3 million individuals have been affected by this deadly virus resulting in about 850,673 deaths. To combat the spread of COVID-19, more than 100 applicant immunizations are being developed around the world. Among them, eight have begun or will be soon beginning preliminary clinical trials. This paper provides a review of the current developments of potential COVID-19 vaccines around the world. It specifically discusses the recombinant vaccine produced by the University of Oxford and AstraZeneca (Cambridge, UK), the use of novel self-amplifying RNA technique to create a vaccine and the progress made by UNAID (US National Institute of Allergy and Infectious Diseases) and World Health Organization (WHO). Furthermore, this review demonstrates the pharmaceutical prophylaxis and treatment protocols for COVID-19 by analysing the documentation set up by the WHO for up to date data with respect to the novel coronavirus of 2019–2020.
机译：Coronavirus疾病2019（Covid-19），SARS-COV-2（严重急性呼吸综合征Coronavirus 2）引起的致命疾病是一个全球大流行，这些大流行都严重影响了全球的生命和经济。如果没有疫苗准备实施，这种病毒的扩散将非常难以包含。这是因为这种病毒的人对人类传输率高，并且病毒在社区传播阶段的事实。截至2020年8月31日，受到这项致命病毒的影响，25.3亿人受到约850,673人死亡。为了打击Covid-19的传播，在世界各地开发了100多个申请人免疫。其中，八人已经开始或将很快开始初步临床试验。本文对全球潜在的Covid-19疫苗进行了审查述评。它专门讨论了牛津大学和阿斯塔伦（Astrazeneca）（剑桥，英国）生产的重组疫苗，使用新型自我放大RNA技术来创造疫苗和联合国（美国国家过敏和传染病学院）和的进展世界卫生组织（世卫组织）。此外，本综述通过分析由2019 - 2019 - 2012年的新型冠状病毒进行了最新数据，分析了Covid-19的药物预防和治疗方案。

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