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首页> 美国卫生研究院文献>Diagnostics >Application of Innovative TGA/Chemometric Approach for Forensic Purposes: The Estimation of the Time since Death in Contaminated Specimens
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Application of Innovative TGA/Chemometric Approach for Forensic Purposes: The Estimation of the Time since Death in Contaminated Specimens

机译：创新TGA / Chemometric方法在法医用途中的应用：污染标本死亡以来的估算

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摘要

Chronothanatology has always been a challenge in forensic sciences. Therefore, the importance of a multidisciplinary approach for the characterization of matrices (organs, tissues, or fluids) that respond linearly to the postmortem interval (PMI) is emerging increasingly. The vitreous humor is particularly suitable for studies aimed at assessing time-related modifications because it is topographically isolated and well-protected. In this work, a novel approach based on thermogravimetry and chemometrics was used to estimate the time since death in the vitreous humor and to collect a databank of samples derived from postmortem examinations after medico–legal evaluation. In this study, contaminated and uncontaminated specimens with tissue fragments were included in order to develop a classification model to predict time of death based on partial least squares discriminant analysis (PLS-DA) that was as robust as possible. Results demonstrate the possibility to correctly predict the PMI even in contaminated samples, with an accuracy not lower than 70%. In addition, the correlation coefficient of the measured versus predicted outcomes was found to be 0.9978, confirming the ability of the model to extend its feasibility even to such situations involving contaminated vitreous humor.
机译：计时学科学一直是法医学的挑战。因此，多学科方法对矩阵（器官，组织或流体）表征的多学科方法越来越多地出现响应追溯间隔（PMI）。玻璃幽默幽默特别适用于旨在评估与时间相关的修改的研究，因为它是拓扑孤立和良好的保护。在这项工作中，基于热重试验和化学测定学的新方法用于估算玻璃体幽默中死亡的时间，并在药物法律评估后收集源自后期检查的样本数据库。在该研究中，包括具有组织片段的污染和未污染的标本，以便开发分类模型以预测基于尽可能稳健的局部最小二乘判别分析（PLS-DA）的死亡时间。结果表明，即使在污染的样品中，也可以正确预测PMI，精度不低于70％。此外，发现测量与预测结果的相关系数为0.9978，确认模型甚至延长其可行性的能力，即使是涉及受污染的玻璃体幽默的这种情况。

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