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首页> 美国卫生研究院文献>Diagnostics >The Activation of Prothrombin Seems to Play an Earlier Role than the Complement System in the Progression of Colorectal Cancer: A Mass Spectrometry Evaluation
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The Activation of Prothrombin Seems to Play an Earlier Role than the Complement System in the Progression of Colorectal Cancer: A Mass Spectrometry Evaluation

机译：凝血酶原的激活似乎比结肠直肠癌进展中的补体系统发挥前进的作用：质谱评价

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摘要

Colorectal cancer (CRC) is the second cause of death in men and the third in women. This work deals with the study of the low molecular weight protein fraction of sera from patients who underwent surgery for CRC and who were followed for several years thereafter. MALDI-TOF MS was used to identify serum peptidome profiles of healthy controls, non-metastatic CRC patients and metastatic CRC patients. A multiple regression model was applied to signals preliminarily selected by SAM analysis to take into account the age and gender differences between the groups. We found that, while a signal m/z 2021.08, corresponding to the C3f fragment of the complement system, appears significantly increased only in serum from metastatic CRC patients, a m/z 1561.72 signal, identified as a prothrombin fragment, has a significantly increased abundance in serum from non-metastatic patients as well. The findings were also validated by a bootstrap resampling procedure. The present results provide the basis for further studies on large cohorts of patients in order to confirm C3f and prothrombin as potential serum biomarkers. Thus, new and non-invasive tests might be developed to improve the classification of colorectal cancer.
机译：结肠直肠癌（CRC）是男性和女性中的第三个死亡的第二个原因。这项工作涉及来自接受CRC手术的患者的血清的低分子量蛋白分​​数的研究，此后持续了几年。 MALDI-TOF MS用于鉴定健康对照，非转移CRC患者和转移性CRC患者的血清肽谱。将多元回归模型应用于SAM分析初步选择的信号，以考虑组之间的年龄和性别差异。我们发现，在对应于补体系统的C3F片段的信号M / Z 2021.08的同时，仅在来自转移CRC患者的血清中显着增加，而am / z 1561.72信号，则鉴定为凝血酶原片段，具有显着增加的丰度在非转移性患者的血清中也是如此。这些发现也通过自动启动重采样程序验证。本结果为进一步研究大型患者的进一步研究提供了基础，以确认C3F和凝血酶原为潜在的血清生物标志物。因此，可能开发出新的和非侵入性测试以改善结肠直肠癌的分类。

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