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首页> 美国卫生研究院文献>European Thyroid Journal >Oxidative Stress in Graves Disease and Graves Orbitopathy
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Oxidative Stress in Graves Disease and Graves Orbitopathy

机译：坟墓疾病和坟墓胰腺炎的氧化应激

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Oxidative stress is involved in the pathogenesis of Graves hyperthyroidism (GH) and Graves orbitopathy (GO) and an antioxidant approach has been proposed for both. In GH, a disbalance of the cell redox state is associated with thyroid hyperfunction and antithyroid medications may reduce oxidative stress. Tissue hypoxia participates in the pathogenesis of GO, and oxygen free radicals are involved in the typical changes of orbital tissues as reported by in vitro and clinical studies. Antioxidant agents, especially selenium, have been proposed as a therapeutic option for GH and GO. A clinical study regarding the use of selenium in mild GO has provided evidence for a beneficial effect in the short term, even though its beneficial effects in the long term are still to be investigated. In addition to selenium, a protective role of other antioxidant agents, i.e., quercetin, enalapril, vitamin C, N-acetyl-L-cysteine and melatonin has been suggested by in vitro studies, although clinical studies are lacking. Here, we review the role of oxidative stress and antioxidant agents in GH and GO.
机译：氧化应激参与坟墓甲状腺功能亢进（GH）的发病机制（GH）和坟墓胰腺病（GO）和抗氧化方法都提出了两者。在GH中，细胞氧化还原状态的丧失与甲状腺高障碍相关，并且抗替代药物可以减少氧化应激。组织缺氧参与Go的发病机制，氧自由基涉及体外和临床研究报道的轨道组织的典型变化。已经提出了抗氧化剂，尤其是硒，作为GH的治疗选择并去。关于使用硒在轻度下硒的临床研究为短期内有益处的证据，即使仍然需要调查其长期的有益效果。除了硒外，还通过体外研究提出了其他抗氧化剂，即槲皮素，烯丙酮，维生素C，N-乙酰-1-半胱氨酸和褪黑素的保护作用，尽管缺乏临床研究。在这里，我们审查了GH的氧化应激和抗氧化剂的作用。

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