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Etiology of febrile respiratory infections in the general adult population in Singapore 2007–2013

机译：红加坡一般成年人口发热呼吸道感染的病因2007-2013

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摘要

Pathogens that cause upper respiratory infections are numerous and specific preventive and therapeutic strategies are scarce. In order to ascertain the etiological agents resulting in upper respiratory tract infections (URTI) in adults in Singapore, nasal swab samples were collected from 2057 patients presenting with fever at primary healthcare clinics in Singapore from December 2007 to February 2013. Samples were tested using the Luminex NxTAG Respiratory Pathogen Panel that includes 22 respiratory pathogen targets. Patient-reported symptoms and vital signs were recorded and full blood and differential counts taken. Pathogens were detected in the following order of frequency: influenza viruses, rhino-/enteroviruses, coronaviruses, parainfluenza viruses, pneumoviruses, adenovirus, bocavirus and C. pneumoniae. Fifteen virus species were detected as part of coinfections, in which rhinoviruses were the most commonly observed pathogen. Our results suggest that influenza viruses are the main etiological agents, but multiple other respiratory viruses contribute to the total burden of URTI in adults in Singapore.
机译：引起上呼吸道感染的病原体是许多，具体的预防和治疗策略都是稀缺的。为了确定新加坡成人中成人中呼吸道感染（URTI）的病因，从2007年12月到2013年12月在新加坡发烧的2057名患者中收集了鼻拭子样品。使用该样品Luminex NXTAG呼吸道病原体面板，包括22个呼吸道病原体靶标。记录了患者报告的症状和生命体征，并进行了全血和差异计数。在以下频率顺序中检测到病原体：流感病毒，犀牛/肠病毒，冠状病毒，肺毛虫病毒，肺病毒，腺病毒，肺病毒和C.肺炎。将十五种病毒物种作为辛纤维的一部分检测到，其中鼻病毒是最常见的病原体。我们的研究结果表明，流感病毒是主要的病因因素，但多种其他呼吸道病毒有助于新加坡成人Urti的全部负担。

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