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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Gender Differences in Oesophageal Squamous Cell Carcinoma in a South African Tertiary Hospital
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Gender Differences in Oesophageal Squamous Cell Carcinoma in a South African Tertiary Hospital

机译：南非高等院医院中食管鳞状细胞癌的性别差异

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(1) Oesophageal squamous cell carcinoma is common in Africa and has a male preponderance. The gender-based differences in clinical presentation and risk factor exposure are poorly studied in the African context. Our aim was to compare males and females with this disease. We analyzed the differences in clinical features and risk factor exposure between males and females with oesophageal cancer. (2) Data from patients presenting to a tertiary hospital in South Africa with oesophageal squamous cell carcinoma were analyzed. Data collected included patient demographics, clinical presentation, pathology and risk factor exposure. (3) Three hundred and sixty three patients were included in the study. The male to female ratio was 1.4:1. The mean age was 66 years for females and 61 years for males (p < 0.0001). A significantly larger percentage of males were underweight compared to females (60% vs. 32%, p < 0.001). There were no differences between the genders with regards to performance status, dysphagia grade and duration and tumor length, location and degree of differentiation. There were significant differences between risk factor exposure between the two genders. Smoking and alcohol consumption was an association in more than 70% of males but in less than 10% of females There was no difference survival. (4) Female patients with oesophageal squamous cell carcinoma (OSCC) are older and have a higher body mass index (BMI) than their male counterparts. Traditionally purported risk factors of smoking and alcohol consumption are infrequent associations with OSCC in female patients and other environmental risk factors may be more relevant in this gender.
机译：（1）Oesophageal鳞状细胞癌在非洲是常见的，并且具有雄性优势。在非洲语境中研究了基于性别的临床表现和危险因素暴露的差异。我们的目标是将雄性和女性与这种疾病进行比较。我们分析了患有食管癌的临床特征和危险因素暴露的差异。 （2）分析来自南非高等院医院的患者的数据进行分析。分析了具有食管鳞状细胞癌的患者。收集的数据包括患者人口统计数据，临床介绍，病理和风险因素暴露。 （3）研究中包含三百六十三名患者。男性比例为1.4：1。女性的平均年龄为66岁，男性61岁（P <0.0001）。与雌性相比，较大的雄性百分比体积不足（60％对32％，P <0.001）。在性能状态，吞咽等级和持续时间和肿瘤长度，位置和分化程度方面没有差异。两者之间的风险因素曝光之间存在显着差异。吸烟和酒精消费是超过70％的男性的关联，但不到10％的女性没有差异生存。 （4）患有食管鳞状细胞癌（OSCC）的女性患者年龄较大，具有比其男性对应物更高的体重指数（BMI）。传统上，旨在的吸烟和酗酒的危险因素与女性患者中的OSCC有常见的关联，其他环境风险因素可能在这种性别中更为重要。

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