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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Serum Calprotectin and Chemerin Concentrations as Markers of Low-Grade Inflammation in Prepubertal Children with Obesity
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Serum Calprotectin and Chemerin Concentrations as Markers of Low-Grade Inflammation in Prepubertal Children with Obesity

机译：血清CalProtectin和Chemerin浓度作为肥胖的预接种儿童低级炎症的标志物

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In adults, obesity is associated with chronic low-grade inflammation, which may cause long-term adverse health consequences. We evaluated whether obesity in prepubertal children also generates this kind of inflammation and whether calprotectin and chemerin may be useful markers for early detection of such inflammation in this group of children. The study population included 83 children aged 2 to 10 years; 62 with obesity and without components of metabolic syndrome and 21 healthy controls with normal body weight. White blood cell (WBC) count, concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), calprotectin, and chemerin were determined in peripheral blood. Our study showed that in the group with obesity, serum concentrations of calprotectin and chemerin, as well as CRP were significantly higher as compared with the controls. We found a significant positive correlation between serum chemerin concentrations and BMI z-score (r = 0.33, p < 0.01) in children with obesity. Chemerin concentration was also positively correlated with CRP level (r = 0.36, p < 0.01) in the whole group of children. These findings suggest that obesity may generate chronic low-grade inflammation as early as in the prepubertal period which can be indicated by significantly higher serum concentrations of calprotectin and chemerin. Calprotectin and especially chemerin seem to be promising indicators of this type of inflammation in children with obesity, but the correlation between these markers requires further research.
机译：在成人中，肥胖与慢性低级炎症有关，可能导致长期不良健康后果。我们评估了预接种儿童的肥胖是否也产生这种炎症，并且钙蛋白质和Chemerin是否可能是用于早期检测该组儿童这种炎症的有用标记。研究人口包括83名年龄在2至10年的儿童; 62具有肥胖症，没有代谢综合征的组分和21种健康对照，具有正常体重。在外周血中测定白细胞（WBC）计数，C反应蛋白（CRP），白细胞介素-6（IL-6），CalProtectin和Chemerin的浓度。我们的研究表明，与肥胖的血清浓度和Chemerin的血清浓度，以及CRP与对照相比显着高。我们发现血清培养素浓度与BMI Z-评分（R = 0.33，P <0.01）之间的显着正相关性。在整个儿童中，Chemerin浓度也与CRP水平（R = 0.36，P <0.01）正相关。这些研究结果表明，早期可能会产生慢性低级炎症，如预期期间，可以通过显着更高的CalProtectin和Chemerin的血清浓度来表明。 CalProtectin，特别是Chemerin似乎是具有肥胖的儿童这种类型的炎症的有希望的指标，但这些标志物之间的相关性需要进一步研究。

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