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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Therapeutic Potential of the Natural Compound S-Adenosylmethionine as a Chemoprotective Synergistic Agent in Breast and Head and Neck Cancer Treatment: Current Status of Research
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Therapeutic Potential of the Natural Compound S-Adenosylmethionine as a Chemoprotective Synergistic Agent in Breast and Head and Neck Cancer Treatment: Current Status of Research

机译：天然化合物S-腺苷甲基硫醚的治疗潜力作为乳腺癌的化学防护协同剂头部和颈部癌症治疗：当前研究现状

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摘要

The present review summarizes the most recent studies focusing on the synergistic antitumor effect of the physiological methyl donor S-adenosylmethionine (AdoMet) in association with the main drugs used against breast cancer and head and neck squamous cell carcinoma (HNSCC), two highly aggressive and metastatic malignancies. In these two tumors the chemotherapy approach is recommended as the first choice despite the numerous side effects and recurrence of metastasis, so better tolerated treatments are needed to overcome this problem. In this regard, combination therapy with natural compounds, such as AdoMet, a molecule with pleiotropic effects on multiple cellular processes, is emerging as a suitable strategy to achieve synergistic anticancer efficacy. In this context, the analysis of studies conducted in the literature highlighted AdoMet as one of the most effective and promising chemosensitizing agents to be taken into consideration for inclusion in emerging antitumor therapeutic modalities such as nanotechnologies.
机译：本综述总结了重点研究生理甲基供体S-腺苷（Adomet）与乳腺癌和头部鳞状细胞癌（HNSCC）的主要药物相关联的生理甲基供体S-腺苷（Adomet）的协同抗肿瘤效应，两项高度侵略性和转移性恶性肿瘤。在这两种肿瘤中，尽管转移的许多副作用和复发，所以建议化疗方法是第一选择，因此需要更好的耐受性治疗来克服这个问题。在这方面，用对多个细胞过程具有抗脂肪效应的天然化合物的组合治疗，例如具有胃酸过程的分子，是达到协同抗癌效力的合适策略。在这种情况下，在文献中进行的研究突出显示了Adomet，作为最有效和有前途的化学溶剂化试剂之一，以考虑到纳入新出现的抗肿瘤治疗方式，例如纳米技术。

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