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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Changes in the Physicochemical Properties of Blood and Skin Cell Membranes as a Result of Psoriasis Vulgaris and Psoriatic Arthritis Development
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Changes in the Physicochemical Properties of Blood and Skin Cell Membranes as a Result of Psoriasis Vulgaris and Psoriatic Arthritis Development

机译：牛皮癣和银屑病关节炎发展导致血液和皮肤细胞膜的物理化学特性的变化

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摘要

Psoriasis is accompanied by disturbed redox homeostasis, with systemic and local oxidative stress promoting the modification of basic components of cellular membranes. Therefore, the aim of the study was to investigate the effect of development of psoriasis vulgaris and psoriatic arthritis on the composition and physicochemical properties of skin cell membranes (keratinocytes and fibroblasts) and blood cells (lymphocytes, granulocytes and erythrocytes). Both forms of psoriasis are characterized by decreased levels and changes in the localization of membrane phospholipids, and an increased level of sialic acid as well as the lipid peroxidation product (malondialdehyde), which resulted in an increase in the zeta potential of skin cells and blood cells, with granulocytes and lymphocytes affected more than erythrocytes. Using theoretical equations and the dependence of the cell membrane surface charge density as a function of pH, it was shown that patients with psoriatic arthritis have a greater increase in the concentration of negatively charged groups on the membrane surface and reduced the value of the association constant with H+ compared to patients with psoriasis vulgaris. Therefore, it can be suggested that the physicochemical parameters of membranes, skin and blood cells, especially lymphocytes, can be used to assess the severity of the disease.
机译：牛皮癣伴随着干扰的氧化还原稳态，具有全身和局部氧化应激，促进细胞膜的碱性成分的改性。因此，该研究的目的是探讨牛皮癣和银屑病关节炎的发育对皮肤细胞膜（角质形成细胞和成纤维细胞）和血细胞（淋巴细胞，粒细胞和红细胞）的组成和物理化学性质的影响。两种形式的牛皮癣的特征在于膜磷脂的定位的水平降低和变化，以及唾液酸水平增加以及脂质过氧化产物（丙二醛），导致皮肤细胞和血液的Zeta潜力增加细胞，粒细胞和淋巴细胞影响超过红细胞。使用理论方程和细胞膜表面电荷密度作为pH的函数的依赖性，显示了膜表面上带负电的基团的浓度较大的患者，并降低了结合常数的值与H +相比，与牛皮癣患者为寻常的患者。因此，可以建议膜，皮肤和血细胞，尤其是淋巴细胞的物理化学参数可用于评估疾病的严重程度。

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