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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >A Review on the Fate of Legacy and Alternative Antimicrobials and Their Metabolites during Wastewater and Sludge Treatment
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A Review on the Fate of Legacy and Alternative Antimicrobials and Their Metabolites during Wastewater and Sludge Treatment

机译：废水和污泥处理中遗留和替代抗微生物的命运及其代谢物的评论

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摘要

Antimicrobial compounds are used in a broad range of personal care, consumer and healthcare products and are frequently encountered in modern life. The use of these compounds is being reexamined as their safety, effectiveness and necessity are increasingly being questioned by regulators and consumers alike. Wastewater often contains significant amounts of these chemicals, much of which ends up being released into the environment as existing wastewater and sludge treatment processes are simply not designed to treat many of these contaminants. Furthermore, many biotic and abiotic processes during wastewater treatment can generate significant quantities of potentially toxic and persistent antimicrobial metabolites and byproducts, many of which may be even more concerning than their parent antimicrobials. This review article explores the occurrence and fate of two of the most common legacy antimicrobials, triclosan and triclocarban, their metabolites/byproducts during wastewater and sludge treatment and their potential impacts on the environment. This article also explores the fate and transformation of emerging alternative antimicrobials and addresses some of the growing concerns regarding these compounds. This is becoming increasingly important as consumers and regulators alike shift away from legacy antimicrobials to alternative chemicals which may have similar environmental and human health concerns.
机译：抗微生物化合物用于广泛的个人护理，消费和医疗保健产品，经常在现代生活中遇到。这些化合物的使用正在重新审视，因为它们的安全性，有效性和必要性越来越多地受到监管机构和消费者的质疑。废水通常含有大量这些化学品，其中大部分地区最终被释放到环境中，因为现有的废水和污泥处理过程根本不设计用于治疗许多这些污染物。此外，许多废水处理期间的生物和非生物过程可以产生显着的毒性和持续的抗菌代谢物和副产物，其中许多可能比其母体抗微生物剂更大。该审查文章探讨了两种最常见的传统抗微生物，三胞石和三胞菌，它们的废水和污泥处理期间的代谢物/副产物的发生和命运以及它们对环境的潜在影响。本文还探讨了新出现的替代抗菌药物的命运和转型，并对这些化合物的一些越来越多的担忧探讨了。这正变得越来越重要，因为消费者和监管机构远离遗产抗微生物转移到可能具有类似环境和人类健康问题的替代化学品。

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