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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth
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Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth

机译：靶向骨髓微环境中的细胞间通信以防止疏水性和骨转移性肿瘤生长的传播肿瘤细胞逸出

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摘要

Metastasis to the bone is a common feature of many cancers including those of the breast, prostate, lung, thyroid and kidney. Once tumors metastasize to the bone, they are essentially incurable. Bone metastasis is a complex process involving not only intravasation of tumor cells from the primary tumor into circulation, but extravasation from circulation into the bone where they meet an environment that is generally suppressive of their growth. The bone microenvironment can inhibit the growth of disseminated tumor cells (DTC) by inducing dormancy of the DTC directly and later on following formation of a micrometastatic tumour mass by inhibiting metastatic processes including angiogenesis, bone remodeling and immunosuppressive cell functions. In this review we will highlight some of the mechanisms mediating DTC dormancy and the complex relationships which occur between tumor cells and bone resident cells in the bone metastatic microenvironment. These inter-cellular interactions may be important targets to consider for development of novel effective therapies for the prevention or treatment of bone metastases.
机译：转移到骨骼是许多癌症的常见特征，包括乳腺癌，前列腺，肺，甲状腺和肾脏。一旦肿瘤转移到骨骼，它们基本上是可现力的。骨转移是一种复杂的过程，不仅涉及肿瘤细胞从原发性肿瘤进入循环，而且从循环到骨骼中，它们符合通常抑制其生长的环境。通过抑制包括血管生成，骨重塑和免疫抑制细胞功能的转移过程，通过直接诱导DTC的休眠，骨微环境可以通过直接诱导DTC的休眠，通过诱导微转移肿瘤肿块的休眠来抑制散发肿瘤细胞（DTC）的生长。在本文中，我们将突出一些调节DTC休眠和骨转移微环境中肿瘤细胞和骨驻留细胞之间发生的复杂关系的一些机制。这些细胞间相互作用可能是考虑开发用于预防或治疗骨转移的新型有效疗法的重要目标。

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